Seroatlas · Human Serome Atlas

CSPG5

Chondroitin sulfate proteoglycan 5

Also known as: CSPG5_HUMAN, NGC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95196
Gene
CSPG5
Ensembl
ENSG00000114646
Chromosome
3
Canonical length
566 aa
Protein class
Predicted membrane proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane,Cytosol
Secretome location
Secreted in brain

OverviewNCBI Gene

The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>O95196|CSPG5
     1  MGRAGGGGPG RGPPPLLLFL GAALVLASGA VPAREAGSAV EAEELVKGSP AWEPPANDTR
    61  EEAGPPAAGE DEASWTAPGG ELAGPEEVLQ ESAAVTGTAW LEADSPGLGG VTAEAGSGDA
   121  QALPATLQAP HEVLGQSIMP PAIPEATEAS GPPSPTPGDK LSPASELPKE SPLEVWLNLG
   181  GSTPDPQGPE LTYPFQGTLE PQPASDIIDI DYFEGLDGEG RGADLGSFPG SPGTSENHPD
   241  TEGETPSWSL LDLYDDFTPF DESDFYPTTS FYDDLDEEEE EEEDDKDAVG GGDLEDENEL
   301  LVPTGKPGLG PGTGQPTSRW HAVPPQHTLG SVPGSSIALR PRPGEPGRDL ASSENGTECR
   361  SGFVRHNGSC RSVCDLFPSY CHNGGQCYLV ENIGAFCRCN TQDYIWHKGM RCESIITDFQ
   421  VMCVAVGSAA LVLLLLFMMT VFFAKKLYLL KTENTKLRRT NKFRTPSELH NDNFSLSTIA
   481  EGSHPNVRKL CNTPRTSSPH ARALAHYDNV ICQDDPSAPH KIQEVLKSCL KEEESFNIQN
   541  SMSPKLEGGK GDQADLDVNC LQNNLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSPG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
103 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 103 nTPM
  • cerebral cortex: 98 nTPM
  • basal ganglia: 88 nTPM
  • hippocampal formation: 73 nTPM
  • hypothalamus: 58 nTPM
  • choroid plexus: 53 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 319 nCPM
  • retinal pigment epithelial cells: 226 nCPM
  • müller glia: 108 nCPM
  • astrocytes: 84 nCPM
  • respiratory ionocytes: 56 nCPM
  • alveolar cells type 1: 54 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 95 nTPM
  • cerebral cortex: 93 nTPM
  • basal ganglia: 87 nTPM
  • hippocampal formation: 79 nTPM
  • amygdala: 79 nTPM
  • hypothalamus: 61 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.06
gnomAD missense Z
1.34
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Neural chondroitin sulphate proteoglycan cytoplasmic
  • CSPG5, sulphate attachment domain
  • Chondroitin sulphate attachment domain
  • Neural chondroitin sulphate proteoglycan cytoplasmic domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSPG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSPG5 as an antibody target. Whether an autoantibody or antibody against CSPG5 could matter depends on whether native CSPG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSPG5 is annotated at the cell surface, where native CSPG5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CSPG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CSPG5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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