Seroatlas · Human Serome Atlas

FAM170B

Protein FAM170B

Also known as: AC084727.4, C10orf73, F170B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMN3
Gene: FAM170B
Ensembl: ENSG00000172538
Chromosome: 10
Canonical length: 283 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in fertilization; positive regulation of acrosome reaction; and regulation of fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>A6NMN3|FAM170B
     1  MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG PAIPREEGLY
    61  FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN AAPQSVCAFY THVQTVRGVA
   121  VAWETEAGFE PVTRKPRIHE AQFIKRQRWN GSSFEMASNT DMRWDLEACK SNCSPEPEDI
   181  DLLECCLQEL REPPDWLVTT NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM
   241  LERRRAQGQA HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FAM170B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

testis: 6.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 118 nCPM
late spermatids: 28 nCPM
late primary spermatocytes: 11 nCPM
sertoli cells: 1.1 nCPM
neutrophils: 1 nCPM
hofbauer cells: 0.3 nCPM

Immune cell

eosinophil: 1.9 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.7 nTPM
white matter: 0.4 nTPM
pons: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
medulla oblongata: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.45
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FAM170B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GOPC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FAM170B as an antibody target. Whether an autoantibody or antibody against FAM170B could matter depends on whether native FAM170B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FAM170B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FAM170B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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