Seroatlas · Human Serome Atlas

FZD8

Frizzled-8

Also known as: FZD8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H461
Gene: FZD8
Ensembl: ENSG00000177283
Chromosome: 10
Canonical length: 694 aa
Protein class: G-protein coupled receptors, Plasma proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum,Primary cilium

OverviewNCBI Gene

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

694 residues, UniProt reviewed canonical sequence.

>Q9H461|FZD8
     1  MEWGYLLEVT SLLAALALLQ RSSGAAAASA KELACQEITV PLCKGIGYNY TYMPNQFNHD
    61  TQDEAGLEVH QFWPLVEIQC SPDLKFFLCS MYTPICLEDY KKPLPPCRSV CERAKAGCAP
   121  LMRQYGFAWP DRMRCDRLPE QGNPDTLCMD YNRTDLTTAA PSPPRRLPPP PPGEQPPSGS
   181  GHGRPPGARP PHRGGGRGGG GGDAAAPPAR GGGGGGKARP PGGGAAPCEP GCQCRAPMVS
   241  VSSERHPLYN RVKTGQIANC ALPCHNPFFS QDERAFTVFW IGLWSVLCFV STFATVSTFL
   301  IDMERFKYPE RPIIFLSACY LFVSVGYLVR LVAGHEKVAC SGGAPGAGGA GGAGGAAAGA
   361  GAAGAGAGGP GGRGEYEELG AVEQHVRYET TGPALCTVVF LLVYFFGMAS SIWWVILSLT
   421  WFLAAGMKWG NEAIAGYSQY FHLAAWLVPS VKSIAVLALS SVDGDPVAGI CYVGNQSLDN
   481  LRGFVLAPLV IYLFIGTMFL LAGFVSLFRI RSVIKQQDGP TKTHKLEKLM IRLGLFTVLY
   541  TVPAAVVVAC LFYEQHNRPR WEATHNCPCL RDLQPDQARR PDYAVFMLKY FMCLVVGITS
   601  GVWVWSGKTL ESWRSLCTRC CWASKGAAVG GGAGATAAGG GGGPGGGGGG GPGGGGGPGG
   661  GGGSLYSDVS TGLTWRSGTA SSVSYPKQMP LSQV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 19 nTPM
spleen: 11 nTPM
heart muscle: 9.3 nTPM
colon: 8.4 nTPM
blood vessel: 8.3 nTPM
stomach: 6.8 nTPM

Single-cell type

alveolar cells type 1: 58 nCPM
thymic myoid cells: 44 nCPM
parietal cells: 37 nCPM
müller glia: 33 nCPM
pituicytes/fscs: 29 nCPM
breast myoepithelial cells: 22 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 85 nTPM
cerebral cortex: 13 nTPM
basal ganglia: 13 nTPM
hippocampal formation: 12 nTPM
amygdala: 12 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.79
gnomAD missense Z: 3.17
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM
Frizzled domain
Frizzled cysteine-rich domain superfamily
Fz domain
Frizzled/Smoothened family membrane region
Frizzled 8, cysteine-rich domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD8 as an antibody target. Whether an autoantibody or antibody against FZD8 could matter depends on whether native FZD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD8 is annotated at the cell surface, where native FZD8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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