Seroatlas · Human Serome Atlas

FZD5

Frizzled-5

Also known as: C2orf31, DKFZP434E2135, FZD5_HUMAN, HFZ5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13467
Gene
FZD5
Ensembl
ENSG00000163251
Chromosome
2
Canonical length
585 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q13467|FZD5
     1  MARPDPSAPP SLLLLLLAQL VGRAAAASKA PVCQEITVPM CRGIGYNLTH MPNQFNHDTQ
    61  DEAGLEVHQF WPLVEIQCSP DLRFFLCSMY TPICLPDYHK PLPPCRSVCE RAKAGCSPLM
   121  RQYGFAWPER MSCDRLPVLG RDAEVLCMDY NRSEATTAPP RPFPAKPTLP GPPGAPASGG
   181  ECPAGGPFVC KCREPFVPIL KESHPLYNKV RTGQVPNCAV PCYQPSFSAD ERTFATFWIG
   241  LWSVLCFIST STTVATFLID MERFRYPERP IIFLSACYLC VSLGFLVRLV VGHASVACSR
   301  EHNHIHYETT GPALCTIVFL LVYFFGMASS IWWVILSLTW FLAAGMKWGN EAIAGYAQYF
   361  HLAAWLIPSV KSITALALSS VDGDPVAGIC YVGNQNLNSL RGFVLGPLVL YLLVGTLFLL
   421  AGFVSLFRIR SVIKQGGTKT DKLEKLMIRI GIFTLLYTVP ASIVVACYLY EQHYRESWEA
   481  ALTCACPGHD TGQPRAKPEY WVLMLKYFMC LVVGITSGVW IWSGKTVESW RRFTSRCCCR
   541  PRRGHKSGGA MAAGDYPEAS AALTGRTGPP GPAATYHKQV SLSHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FZD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • liver: 21 nTPM
  • duodenum: 18 nTPM
  • colon: 17 nTPM
  • small intestine: 14 nTPM
  • rectum: 14 nTPM
  • stomach: 11 nTPM

Single-cell type

  • alveolar cells type 1: 100 nCPM
  • colonocytes: 97 nCPM
  • alveolar cells type 2: 67 nCPM
  • hepatocytes: 65 nCPM
  • foveolar cells: 62 nCPM
  • müller glia: 57 nCPM

Immune cell

  • classical monocyte: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 14 nTPM
  • midbrain: 12 nTPM
  • cerebral cortex: 9.8 nTPM
  • hypothalamus: 8.8 nTPM
  • choroid plexus: 8.6 nTPM
  • basal ganglia: 8.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FZD5.

Disease | AllUniProt

Conditions FZD5 is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.98
gnomAD missense Z
3
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FZD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FZD5 as an antibody target. Whether an autoantibody or antibody against FZD5 could matter depends on whether native FZD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FZD5 is annotated at the cell surface, where native FZD5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FZD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FZD5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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