F-box domain

Definition

This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; [pfam:PF00560] and [pfam:PF07723]) and the WD repeat ([pfam:PF00400]). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression [[cite:PMID:8706131],[cite:PMID:9346238]].

8 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (8 proteins: gene, accession, name)

• FBXL15
• FBXO22
• FBXO27
• FBXO28
• FBXO38
• FBXO43
• FBXO47
• FBXO5