Seroatlas · Human Serome Atlas

EML3

Echinoderm microtubule-associated protein-like 3

Also known as: ELP95, EMAL3_HUMAN, FLJ35827

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32P44
Gene: EML3
Ensembl: ENSG00000149499
Chromosome: 11
Canonical length: 896 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homotrimer

OverviewNCBI Gene

Predicted to enable microtubule binding activity. Involved in mitotic metaphase chromosome alignment and regulation of mitotic spindle assembly. Located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

896 residues, UniProt reviewed canonical sequence.

>Q32P44|EML3
     1  MDGAAGPGDG PAREALQSLS QRLRVQEQEM ELVKAALAEA LRLLRLQVPP SSLQGSGTPA
    61  PPGDSLAAPP GLPPTCTPSL VSRGTQTETE VELKSSPGPP GLSNGPPAPQ GASEEPSGTQ
   121  SEGGGSSSSG AGSPGPPGIL RPLQPPQRAD TPRRNSSSSS SPSERPRQKL SRKAISSANL
   181  LVRSGSTESR GGKDPLSSPG GPGSRRSNYN LEGISVKMFL RGRPITMYIP SGIRSLEELP
   241  SGPPPETLSL DWVYGYRGRD SRSNLFVLRS GEVVYFIACV VVLYRPGGGP GGPGGGGQRH
   301  YRGHTDCVRC LAVHPDGVRV ASGQTAGVDK DGKPLQPVVH IWDSETLLKL QEIGLGAFER
   361  GVGALAFSAA DQGAFLCVVD DSNEHMLSVW DCSRGMKLAE IKSTNDSVLA VGFNPRDSSC
   421  IVTSGKSHVH FWNWSGGVGV PGNGTLTRKQ GVFGKYKKPK FIPCFVFLPD GDILTGDSEG
   481  NILTWGRSPS DSKTPGRGGA KETYGIVAQA HAHEGSIFAL CLRRDGTVLS GGGRDRRLVQ
   541  WGPGLVALQE AEIPEHFGAV RAIAEGLGSE LLVGTTKNAL LRGDLAQGFS PVIQGHTDEL
   601  WGLCTHPSQN RFLTCGHDRQ LCLWDGESHA LAWSIDLKET GLCADFHPSG AVVAVGLNTG
   661  RWLVLDTETR EIVSDVIDGN EQLSVVRYSP DGLYLAIGSH DNVIYIYSVS SDGAKSSRFG
   721  RCMGHSSFIT HLDWSKDGNF IMSNSGDYEI LYWDVAGGCK QLKNRYESRD REWATYTCVL
   781  GFHVYGVWPD GSDGTDINSL CRSHNERVVA VADDFCKVHL FQYPCARAKA PSRMYGGHGS
   841  HVTSVRFTHD DSHLVSLGGK DASIFQWRVL GAGGAGPAPA TPSRTPSLSP ASSLDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EML3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

esophagus: 49 nTPM
spleen: 43 nTPM
adipose tissue: 37 nTPM
blood vessel: 36 nTPM
ovary: 35 nTPM
breast: 34 nTPM

Single-cell type

esophageal apical cells: 767 nCPM
esophageal suprabasal cells: 213 nCPM
suprabasal keratinocytes: 69 nCPM
esophageal basal cells: 68 nCPM
late spermatids: 47 nCPM
vascular endothelial cells: 28 nCPM

Immune cell

basophil: 8.8 nTPM
eosinophil: 5.7 nTPM
NK-cell: 5.6 nTPM
T-reg: 5.6 nTPM
intermediate monocyte: 4.9 nTPM
naive CD8 T-cell: 4.9 nTPM

Brain region

medulla oblongata: 38 nTPM
thalamus: 37 nTPM
white matter: 35 nTPM
pons: 32 nTPM
midbrain: 29 nTPM
cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: 2.3
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EML3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EML3 as an antibody target. Whether an autoantibody or antibody against EML3 could matter depends on whether native EML3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EML3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EML3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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