Seroatlas · Human Serome Atlas

EML2

Echinoderm microtubule-associated protein-like 2

Also known as: ELP70, EMAL2_HUMAN, EMAP-2, EMAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95834
Gene
EML2
Ensembl
ENSG00000125746
Chromosome
19
Canonical length
649 aa
Protein class
Predicted intracellular proteins
Quaternary structure
Homotrimer

OverviewNCBI Gene

Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Located in mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

649 residues, UniProt reviewed canonical sequence.

>O95834|EML2
     1  MSSFGAGKTK EVIFSVEDGS VKMFLRGRPV PMMIPDELAP TYSLDTRSEL PSCRLKLEWV
    61  YGYRGRDCRA NLYLLPTGEI VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAIHPDMVTI
   121  ATGQVAGTTK EGKPLPPHVR IWDSVSLSTL HVLGLGVFDR AVCCVGFSKS NGGNLLCAVD
   181  ESNDHMLSVW DWAKETKVVD VKCSNEAVLV ATFHPTDPTV LITCGKSHIY FWTLEGGSLS
   241  KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQAVL GAHDGGVFGL
   301  CALRDGTLVS GGGRDRRVVL WGSDYSKLQE VEVPEDFGPV RTVAEGHGDT LYVGTTRNSI
   361  LQGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSDSHQ PLWSRIIEDP
   421  ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH
   481  DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSSC FVTNSGDYEI LYWDPATCKQ
   541  ITSADAVRNM EWATATCVLG FGVFGIWSEG ADGTDINAVA RSHDGKLLAS ADDFGKVHLF
   601  SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EML2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 52 nTPM
  • retina: 46 nTPM
  • spinal cord: 41 nTPM
  • esophagus: 37 nTPM
  • midbrain: 37 nTPM
  • skin: 36 nTPM

Single-cell type

  • rod photoreceptor cells: 266 nCPM
  • syncytiotrophoblasts: 183 nCPM
  • cytotrophoblasts: 128 nCPM
  • esophageal apical cells: 112 nCPM
  • oligodendrocytes: 104 nCPM
  • early spermatids: 104 nCPM

Immune cell

  • basophil: 7.9 nTPM
  • memory CD8 T-cell: 6.8 nTPM
  • gdT-cell: 6.6 nTPM
  • plasmacytoid DC: 6.5 nTPM
  • T-reg: 5.8 nTPM
  • eosinophil: 5.7 nTPM

Brain region

  • medulla oblongata: 137 nTPM
  • white matter: 132 nTPM
  • pons: 126 nTPM
  • cerebral cortex: 111 nTPM
  • cerebellum: 107 nTPM
  • basal ganglia: 101 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
-0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EML2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EML2 as an antibody target. Whether an autoantibody or antibody against EML2 could matter depends on whether native EML2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EML2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EML2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EML2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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