Seroatlas · Human Serome Atlas

HAUS6

HAUS augmin-like complex subunit 6

Also known as: dgt6, FAM29A, FLJ20060, HAUS6_HUMAN, KIAA1574

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4H7
Gene: HAUS6
Ensembl: ENSG00000147874
Chromosome: 9
Canonical length: 955 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Centriolar satellite,Cytosol,Acrosome,Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. This protein may have a role in efficient chromosome congression and segregation by promoting microtubule-dependent microtubule amplification. Pseudogenes of this gene are located on chromosomes 7 and 20. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

955 residues, UniProt reviewed canonical sequence.

>Q7Z4H7|HAUS6
     1  MSSASVTAFE KEHLWMYLQA LGFEPGPATI ACGKIVSHTH LGVNMFDKLN RDAFHIISYF
    61  LFQVLDQSLT KEVFKFCWPP FDQKSDTEFR KHCCEWIKRI SGECGSSFPQ VVGSLFLSPG
   121  GPKFIHLMYH FARFVAMKYI KSNSKNSSHH FVETFNIKPQ DLHKCIARCH FARSRFLQIL
   181  QRQDCVTQKY QENAQLSVKQ VRNLRSECIG LENQIKKMEP YDDHSNMEEK IQKVRSLWAS
   241  VNETLMFLEK EREVVSSVLS LVNQYALDGT NVAINIPRLL LDKIEKQMFQ LHIGNVYEAG
   301  KLNLLTVIQL LNEVLKVMKY ERCQADQARL TVDLHYLEKE TKFQKERLSD LKHMRYRIKD
   361  DLTTIRHSVV EKQGEWHKKW KEFLGLSPFS LIKGWTPSVD LLPPMSPLSF DPASEEVYAK
   421  SILCQYPASL PDAHKQHNQE NGCRGDSDTL GALHDLANSP ASFLSQSVSS SDRNSVTVLE
   481  KDTKMGTPKE KNEAISKKIP EFEVENSPLS DVAKNTESSA FGGSLPAKKS DPFQKEQDHL
   541  VEEVARAVLS DSPQLSEGKE IKLEELIDSL GSNPFLTRNQ IPRTPENLIT EIRSSWRKAI
   601  EMEENRTKEP IQMDAEHREV LPESLPVLHN QREFSMADFL LETTVSDFGQ SHLTEEKVIS
   661  DCECVPQKHV LTSHIDEPPT QNQSDLLNKK VICKQDLECL AFTKLSETSR METFSPAVGN
   721  RIDVMGGSEE EFMKILDHLE VSCNKPSTNK TMLWNSFQIS SGISSKSFKD NDFGILHETL
   781  PEEVGHLSFN SSSSSEANFK LEPNSPMHGG TLLEDVVGGR QTTPESDFNL QALRSRYEAL
   841  KKSLSKKREE SYLSNSQTPE RHKPELSPTP QNVQTDDTLN FLDTCDLHTE HIKPSLRTSI
   901  GERKRSLSPL IKFSPVEQRL RTTIACSLGE LPNLKEEDIL NKSLDAKEPP SDLTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
bone marrow: 16 nTPM
thymus: 14 nTPM
lymph node: 11 nTPM
tonsil: 10 nTPM
breast: 8.6 nTPM

Single-cell type

early spermatids: 132 nCPM
erythrocyte progenitors: 102 nCPM
late primary spermatocytes: 92 nCPM
early primary spermatocytes: 88 nCPM
monocyte progenitors: 65 nCPM
megakaryocyte progenitors: 58 nCPM

Immune cell

basophil: 9.8 nTPM
NK-cell: 5 nTPM
MAIT T-cell: 3.9 nTPM
T-reg: 3.7 nTPM
memory CD8 T-cell: 3.6 nTPM
naive CD4 T-cell: 3.3 nTPM

Brain region

white matter: 23 nTPM
cerebellum: 23 nTPM
basal ganglia: 19 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 18 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0
gnomAD missense Z: -2.18
DepMap mean gene effect: -1.26
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAUS augmin-like complex subunit 6
HAUS augmin-like complex subunit 6, N-terminal
HAUS augmin-like complex subunit 6 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS6 as an antibody target. Whether an autoantibody or antibody against HAUS6 could matter depends on whether native HAUS6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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