Seroatlas · Human Serome Atlas

TUBG1

Tubulin gamma-1 chain

Also known as: TBG1_HUMAN, TUBG, TUBGCP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P23258
Gene: TUBG1
Ensembl: ENSG00000131462
Chromosome: 17
Canonical length: 451 aa
Protein class: Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Principal piece

OverviewNCBI Gene

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

451 residues, UniProt reviewed canonical sequence.

>P23258|TUBG1
     1  MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV FFYQADDEHY
    61  IPRAVLLDLE PRVIHSILNS PYAKLYNPEN IYLSEHGGGA GNNWASGFSQ GEKIHEDIFD
   121  IIDREADGSD SLEGFVLCHS IAGGTGSGLG SYLLERLNDR YPKKLVQTYS VFPNQDEMSD
   181  VVVQPYNSLL TLKRLTQNAD CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST
   241  TTLRYPGYMN NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
   301  KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP WGPASIQVAL
   361  SRKSPYLPSA HRVSGLMMAN HTSISSLFER TCRQYDKLRK REAFLEQFRK EDMFKDNFDE
   421  MDTSREIVQQ LIDEYHAATR PDYISWGTQE Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TUBG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 155 nTPM

Expression across tissuesHPA

Tissue

testis: 155 nTPM
skeletal muscle: 55 nTPM
bone marrow: 49 nTPM
pancreas: 46 nTPM
heart muscle: 39 nTPM
tongue: 34 nTPM

Single-cell type

early spermatids: 754 nCPM
late spermatids: 709 nCPM
late primary spermatocytes: 424 nCPM
early primary spermatocytes: 292 nCPM
erythrocyte progenitors: 184 nCPM
extravillous trophoblasts: 94 nCPM

Immune cell

plasmacytoid DC: 44 nTPM
non-classical monocyte: 28 nTPM
intermediate monocyte: 25 nTPM
myeloid DC: 16 nTPM
naive B-cell: 15 nTPM
memory B-cell: 15 nTPM

Brain region

cerebral cortex: 37 nTPM
thalamus: 29 nTPM
choroid plexus: 29 nTPM
medulla oblongata: 27 nTPM
pons: 27 nTPM
hypothalamus: 26 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TUBG1.

Disease | AllUniProt

Conditions TUBG1 is implicated in, by any mechanism.

Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) MIM:615412

Disease | GeneticClinVar

13 pathogenic / likely-pathogenic of 227 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Complex cortical dysplasia with other brain malformations 4
Lissencephaly
Inborn genetic diseases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.13
gnomAD missense Z: 4.16
DepMap mean gene effect: -1.45
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TUBG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TUBG1 as an antibody target. Whether an autoantibody or antibody against TUBG1 could matter depends on whether native TUBG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TUBG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TUBG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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