Seroatlas · Human Serome Atlas

HAUS5

HAUS augmin-like complex subunit 5

Also known as: dgt5, HAUS5_HUMAN, KIAA0841

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94927
Gene: HAUS5
Ensembl: ENSG00000249115
Chromosome: 19
Canonical length: 633 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

Canonical amino-acid sequenceUniProt

633 residues, UniProt reviewed canonical sequence.

>O94927|HAUS5
     1  MELAQEAREL GCWAVEEMGV PVAARAPEST LRRLCLGQGA DIWAYILQHV HSQRTVKKIR
    61  GNLLWYGHQD SPQVRRKLEL EAAVTRLRAE IQELDQSLEL MERDTEAQDT AMEQARQHTQ
   121  DTQRRALLLR AQAGAMRRQQ HTLRDPMQRL QNQLRRLQDM ERKAKVDVTF GSLTSAALGL
   181  EPVVLRDVRT ACTLRAQFLQ NLLLPQAKRG SLPTPHDDHF GTSYQQWLSS VETLLTNHPP
   241  GHVLAALEHL AAEREAEIRS LCSGDGLGDT EISRPQAPDQ SDSSQTLPSM VHLIQEGWRT
   301  VGVLVSQRST LLKERQVLTQ RLQGLVEEVE RRVLGSSERQ VLILGLRRCC LWTELKALHD
   361  QSQELQDAAG HRQLLLRELQ AKQQRILHWR QLVEETQEQV RLLIKGNSAS KTRLCRSPGE
   421  VLALVQRKVV PTFEAVAPQS RELLRCLEEE VRHLPHILLG TLLRHRPGEL KPLPTVLPSI
   481  HQLHPASPRG SSFIALSHKL GLPPGKASEL LLPAAASLRQ DLLLLQDQRS LWCWDLLHMK
   541  TSLPPGLPTQ ELLQIQASQE KQQKENLGQA LKRLEKLLKQ ALERIPELQG IVGDWWEQPG
   601  QAALSEELCQ GLSLPQWRLR WVQAQGALQK LCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

testis: 11 nTPM
ovary: 11 nTPM
cerebellum: 9.1 nTPM
cervix: 8.5 nTPM
spleen: 7.8 nTPM
fallopian tube: 6.8 nTPM

Single-cell type

early primary spermatocytes: 119 nCPM
differentiating spermatogonia: 29 nCPM
late primary spermatocytes: 20 nCPM
ovarian stromal cells: 19 nCPM
esophageal basal cells: 19 nCPM
cytotrophoblasts: 19 nCPM

Immune cell

NK-cell: 4.2 nTPM
memory B-cell: 3.4 nTPM
gdT-cell: 3 nTPM
MAIT T-cell: 3 nTPM
naive CD4 T-cell: 3 nTPM
memory CD4 T-cell: 2.9 nTPM

Brain region

cerebellum: 6.3 nTPM
white matter: 5.4 nTPM
pons: 4.8 nTPM
cerebral cortex: 4.6 nTPM
medulla oblongata: 4.6 nTPM
basal ganglia: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.73
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -1.26
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAUS complex subunit 5, metazoa
HAUS augmin-like complex subunit 5
HAUS augmin-like complex subunit 5

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS5 as an antibody target. Whether an autoantibody or antibody against HAUS5 could matter depends on whether native HAUS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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