Seroatlas · Human Serome Atlas

HAUS3

HAUS augmin-like complex subunit 3

Also known as: C4orf15, dgt3, HAUS3_HUMAN, IT1, MGC4701

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CZ6
Gene: HAUS3
Ensembl: ENSG00000214367
Chromosome: 4
Canonical length: 603 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Primary cilium,Basal body

OverviewNCBI Gene

This gene encodes a component of the HAUS augmin-like protein complex, which plays a key role in cytokinesis and mitosis. Disruption of the encoded protein causes mitotic defects resulting from fragmentation of centrosomes and microtubule destabilization. This gene shares its 5' exons with some transcripts from overlapping GeneID: 353497, which encodes a DNA polymerase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

603 residues, UniProt reviewed canonical sequence.

>Q68CZ6|HAUS3
     1  MSCGNEFVET LKKIGYPKAD NLNGEDFDWL FEGVEDESFL KWFCGNVNEQ NVLSERELEA
    61  FSILQKSGKP ILEGAALDEA LKTCKTSDLK TPRLDDKELE KLEDEVQTLL KLKNLKIQRR
   121  NKCQLMASVT SHKSLRLNAK EEEATKKLKQ SQGILNAMIT KISNELQALT DEVTQLMMFF
   181  RHSNLGQGTN PLVFLSQFSL EKYLSQEEQS TAALTLYTKK QFFQGIHEVV ESSNEDNFQL
   241  LDIQTPSICD NQEILEERRL EMARLQLAYI CAQHQLIHLK ASNSSMKSSI KWAEESLHSL
   301  TSKAVDKENL DAKISSLTSE IMKLEKEVTQ IKDRSLPAVV RENAQLLNMP VVKGDFDLQI
   361  AKQDYYTARQ ELVLNQLIKQ KASFELLQLS YEIELRKHRD IYRQLENLVQ ELSQSNMMLY
   421  KQLEMLTDPS VSQQINPRNT IDTKDYSTHR LYQVLEGENK KKELFLTHGN LEEVAEKLKQ
   481  NISLVQDQLA VSAQEHSFFL SKRNKDVDML CDTLYQGGNQ LLLSDQELTE QFHKVESQLN
   541  KLNHLLTDIL ADVKTKRKTL ANNKLHQMER EFYVYFLKDE DYLKDIVENL ETQSKIKAVS
   601  LED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 25 nTPM
lymph node: 9.4 nTPM
thymus: 7.9 nTPM
spleen: 7.8 nTPM
tonsil: 7.7 nTPM
skin: 7.3 nTPM

Single-cell type

brain excitatory neurons: 5 nCPM
microglia: 4 nCPM
bergmann glia: 3.7 nCPM
other brain neurons: 3.6 nCPM
brain inhibitory neurons: 3.3 nCPM
astrocytes: 3.1 nCPM

Immune cell

eosinophil: 12 nTPM
T-reg: 12 nTPM
NK-cell: 11 nTPM
MAIT T-cell: 10 nTPM
basophil: 9.5 nTPM
naive CD4 T-cell: 9.5 nTPM

Brain region

cerebellum: 25 nTPM
cerebral cortex: 15 nTPM
white matter: 15 nTPM
midbrain: 14 nTPM
medulla oblongata: 13 nTPM
amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: -1.16
DepMap mean gene effect: -1.17
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAUS augmin-like complex subunit 3
HAUS augmin-like complex subunit 3, N-terminal
HAUS augmin-like complex subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS3 as an antibody target. Whether an autoantibody or antibody against HAUS3 could matter depends on whether native HAUS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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