Seroatlas · Human Serome Atlas

HAUS4

HAUS augmin-like complex subunit 4

Also known as: C14orf94, FLJ20424, HAUS4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6D7
Gene: HAUS4
Ensembl: ENSG00000092036
Chromosome: 14
Canonical length: 363 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

363 residues, UniProt reviewed canonical sequence.

>Q9H6D7|HAUS4
     1  MASGDFCSPG EGMEILQQVC SKQLPPCNLS KEDLLQNPYF SKLLLNLSQH VDESGLSLTL
    61  AKEQAQAWKE VRLHKTTWLR SEILHRVIQE LLVDYYVKIQ DTNVTSEDKK FHETLEQRLL
   121  VTELMRLLGP SQEREIPPLL GLEKADLLEL MPLSEDFVWM RARLQQEVEE QLKKKCFTLL
   181  CYYDPNSDAD SETVKAAKVW KLAEVLVGEQ QQCQDAKSQQ KEQMLLLEKK SAAYSQVLLR
   241  CLTLLQRLLQ EHRLKTQSEL DRINAQYLEV KCGAMILKLR MEELKILSDT YTVEKVEVHR
   301  LIRDRLEGAI HLQEQDMENS RQVLNSYEVL GEEFDRLVKE YTVLKQATEN KRWALQEFSK
   361  VYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 60 nTPM
ovary: 51 nTPM
pancreas: 45 nTPM
lymph node: 38 nTPM
spleen: 38 nTPM
breast: 37 nTPM

Single-cell type

enteric stem cells: 46 nCPM
enteric transient amplifying cells: 44 nCPM
paneth cells: 39 nCPM
microglia: 38 nCPM
neutrophils: 29 nCPM
bergmann glia: 28 nCPM

Immune cell

myeloid DC: 102 nTPM
neutrophil: 101 nTPM
classical monocyte: 80 nTPM
intermediate monocyte: 54 nTPM
total PBMC: 46 nTPM
T-reg: 43 nTPM

Brain region

white matter: 21 nTPM
medulla oblongata: 21 nTPM
choroid plexus: 19 nTPM
midbrain: 19 nTPM
spinal cord: 18 nTPM
thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.02
gnomAD missense Z: 0.81
DepMap mean gene effect: -1.26
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule minus-end binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAUS augmin-like complex subunit 4, metazoa
HAUS augmin-like complex subunit 4
HAUS augmin-like complex subunit 4

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS4 as an antibody target. Whether an autoantibody or antibody against HAUS4 could matter depends on whether native HAUS4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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