Seroatlas · Human Serome Atlas

HAUS1

HAUS augmin-like complex subunit 1

Also known as: CCDC5, FLJ40084, HAUS1_HUMAN, HEI-C, HsT1461

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CS2
Gene
HAUS1
Ensembl
ENSG00000152240
Chromosome
18
Canonical length
278 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Cytosol,Mid piece,End piece

OverviewNCBI Gene

HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>Q96CS2|HAUS1
     1  MEPQEERETQ VAAWLKKIFG DHPIPQYEVN PRTTEILHHL SERNRVRDRD VYLVIEDLKQ
    61  KASEYESEAK YLQDLLMESV NFSPANLSST GSRYLNALVD SAVALETKDT SLASFIPAVN
   121  DLTSDLFRTK SKSEEIKIEL EKLEKNLTAT LVLEKCLQED VKKAELHLST ERAKVDNRRQ
   181  NMDFLKAKSE EFRFGIKAAE EQLSARGMDA SLSHQSLVAL SEKLARLKQQ TIPLKKKLES
   241  YLDLMPNPSL AQVKIEEAKR ELDSIEAELT RRVDMMEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 39 nTPM
  • tonsil: 37 nTPM
  • epididymis: 37 nTPM
  • bone marrow: 36 nTPM
  • lymph node: 33 nTPM
  • ovary: 31 nTPM

Single-cell type

  • extravillous trophoblasts: 133 nCPM
  • migrating cytotrophoblasts: 108 nCPM
  • erythrocyte progenitors: 87 nCPM
  • megakaryocytes: 87 nCPM
  • oocytes: 83 nCPM
  • megakaryocyte progenitors: 81 nCPM

Immune cell

  • T-reg: 100 nTPM
  • memory B-cell: 80 nTPM
  • naive B-cell: 65 nTPM
  • plasmacytoid DC: 63 nTPM
  • myeloid DC: 58 nTPM
  • NK-cell: 56 nTPM

Brain region

  • choroid plexus: 6.9 nTPM
  • spinal cord: 4.9 nTPM
  • white matter: 4.8 nTPM
  • hypothalamus: 4.7 nTPM
  • pons: 4.5 nTPM
  • medulla oblongata: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.3
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
-1.6
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • HAUS augmin-like complex subunit 1
  • HAUS augmin-like complex subunit 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS1 as an antibody target. Whether an autoantibody or antibody against HAUS1 could matter depends on whether native HAUS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HAUS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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