Seroatlas · Human Serome Atlas

HAUS8

HAUS augmin-like complex subunit 8

Also known as: HAUS8_HUMAN, HICE1, MGC20533, NY-SAR-48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT25
Gene: HAUS8
Ensembl: ENSG00000131351
Chromosome: 19
Canonical length: 410 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q9BT25|HAUS8
     1  MADSSGRGAG KPATGPTNSS SAKKKDKRVQ GGRVIESRYL QYEKKTTQKA PAGDGSQTRG
    61  KMSEGGRKSS LLQKSKADSS GVGKGDLQST LLEGHGTAPP DLDLSAINDK SIVKKTPQLA
   121  KTISKKPEST SFSAPRKKSP DLSEAMEMME SQTLLLTLLS VKMENNLAEF ERRAEKNLLI
   181  MCKEKEKLQK KAHELKRRLL LSQRKRELAD VLDAQIEMLS PFEAVATRFK EQYRTFATAL
   241  DTTRHELPVR SIHLEGDGQQ LLDALQHELV TTQRLLGELD VGDSEENVQV LDLLSELKDV
   301  TAKKDLELRR SFAQVLELSA EASKEAALAN QEVWEETQGM APPSRWYFNQ DSACRESGGA
   361  PKNTPLSEDD NPGASSAPAQ ATFISPSEDF SSSSQAEVPP SLSRSGRDLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

lymph node: 14 nTPM
tonsil: 13 nTPM
testis: 11 nTPM
bone marrow: 11 nTPM
thymus: 8.9 nTPM
appendix: 7.1 nTPM

Single-cell type

oocytes: 78 nCPM
differentiating spermatogonia: 59 nCPM
early primary spermatocytes: 53 nCPM
migrating cytotrophoblasts: 44 nCPM
undifferentiated spermatogonia: 42 nCPM
cytotrophoblasts: 39 nCPM

Immune cell

intermediate monocyte: 15 nTPM
non-classical monocyte: 14 nTPM
memory B-cell: 12 nTPM
T-reg: 11 nTPM
naive B-cell: 11 nTPM
naive CD4 T-cell: 8.7 nTPM

Brain region

cerebellum: 3.1 nTPM
medulla oblongata: 2.5 nTPM
hypothalamus: 2.4 nTPM
cerebral cortex: 2.3 nTPM
thalamus: 2.3 nTPM
white matter: 2.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.85
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS8 as an antibody target. Whether an autoantibody or antibody against HAUS8 could matter depends on whether native HAUS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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