WD repeat Echinoderm Microtubule-associated Protein-like
IPR050630
Definition
The WD repeat EMAP family is involved in the regulation and modification of microtubule dynamics. Members of this family play crucial roles in the assembly, stability, and length of microtubules, affecting processes such as mitotic spindle organization, chromosome alignment during metaphase, and cell division orientation. Some proteins within this family are essential for normal brain development and neuronal progenitor cell proliferation. Others are implicated in ciliary and flagellar motility, contributing to spermatozoa motility and proper beating of cilia and flagella. The family includes proteins with a tandem atypical propeller in EMLs (TAPE) domain, which is characterized by a unique beta-propeller structure.
9 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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