Seroatlas · Human Serome Atlas

NEK7

Serine/threonine-protein kinase Nek7

Also known as: NEK7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TDX7
Gene: NEK7
Ensembl: ENSG00000151414
Chromosome: 1
Canonical length: 302 aa
Protein class: Enzymes, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm

OverviewNCBI Gene

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>Q8TDX7|NEK7
     1  MDEQSQGMQG PPVPQFQPQK ALRPDMGYNT LANFRIEKKI GRGQFSEVYR AACLLDGVPV
    61  ALKKVQIFDL MDAKARADCI KEIDLLKQLN HPNVIKYYAS FIEDNELNIV LELADAGDLS
   121  RMIKHFKKQK RLIPERTVWK YFVQLCSALE HMHSRRVMHR DIKPANVFIT ATGVVKLGDL
   181  GLGRFFSSKT TAAHSLVGTP YYMSPERIHE NGYNFKSDIW SLGCLLYEMA ALQSPFYGDK
   241  MNLYSLCKKI EQCDYPPLPS DHYSEELRQL VNMCINPDPE KRPDVTYVYD VAKRMHACTA
   301  SS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEK7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 131 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 131 nTPM
adipose tissue: 60 nTPM
tongue: 60 nTPM
skeletal muscle: 53 nTPM
blood vessel: 52 nTPM
spinal cord: 48 nTPM

Single-cell type

neutrophils: 794 nCPM
adrenal cortex cells: 612 nCPM
cardiomyocytes: 429 nCPM
ocular epithelial cells: 377 nCPM
hematopoietic stem cells: 342 nCPM
monocytes: 289 nCPM

Immune cell

MAIT T-cell: 13 nTPM
neutrophil: 6 nTPM
T-reg: 6 nTPM
memory CD8 T-cell: 4.1 nTPM
NK-cell: 3.6 nTPM
eosinophil: 3.3 nTPM

Brain region

white matter: 109 nTPM
medulla oblongata: 105 nTPM
spinal cord: 104 nTPM
basal ganglia: 99 nTPM
hypothalamus: 96 nTPM
pons: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.88
gnomAD missense Z: 2.29
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEK7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEK7 as an antibody target. Whether an autoantibody or antibody against NEK7 could matter depends on whether native NEK7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEK7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NEK7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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