Seroatlas · Human Serome Atlas

HAUS2

HAUS augmin-like complex subunit 2

Also known as: C15orf25, CEP27, FLJ10460, HAUS2_HUMAN, HsT17025

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVX0
Gene: HAUS2
Ensembl: ENSG00000137814
Chromosome: 15
Canonical length: 235 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a subunit of the augmin complex. The augmin complex plays a role in microtubule attachment to the kinetochore and central spindle formation. [provided by RefSeq, Apr 2016]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9NVX0|HAUS2
     1  MAAANPWDPA SAPNGAGLVL GHFIASGMVN QEMLNMSKKT VSCFVNFTRL QQITNIQAEI
    61  YQKNLEIELL KLEKDTADVV HPFFLAQKCH TLQSMNNHLE AVLKEKRSLR QRLLKPMCQE
   121  NLPIEAVYHR YMVHLLELAV TFIERLETHL ETIRNIPHLA ANLKKMNQAL AKMDILVTET
   181  EELAENILKW RKQQNEVSSC IPKILAEESY LYKHDIIMPP LPFTSKVHVQ TINAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HAUS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 34 nTPM
spinal cord: 8.8 nTPM
thymus: 8.3 nTPM
lymph node: 7.5 nTPM
adipose tissue: 7.4 nTPM
tonsil: 7.4 nTPM

Single-cell type

erythrocyte progenitors: 86 nCPM
late primary spermatocytes: 63 nCPM
neutrophil progenitors: 60 nCPM
oocytes: 51 nCPM
rod photoreceptor cells: 48 nCPM
monocyte progenitors: 46 nCPM

Immune cell

non-classical monocyte: 7.5 nTPM
memory B-cell: 5.9 nTPM
intermediate monocyte: 5.2 nTPM
T-reg: 5.2 nTPM
naive B-cell: 5 nTPM
MAIT T-cell: 4.4 nTPM

Brain region

cerebral cortex: 22 nTPM
white matter: 17 nTPM
pons: 14 nTPM
medulla oblongata: 14 nTPM
spinal cord: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.77
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAUS augmin-like complex subunit 2, metazoa
HAUS augmin-like complex subunit 2
HAUS augmin-like complex subunit 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HAUS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HAUS2 as an antibody target. Whether an autoantibody or antibody against HAUS2 could matter depends on whether native HAUS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HAUS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HAUS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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