Helicase-associated domain

Definition

This is the helicase associated domain (HA2) found as a diverse set of RNA helicases. It has an all α-helical fold that can be divided in two subdomains, an N-terminal degenerated winged helix (WH) and a C-terminal ratchet-like domain [[cite:PMID:26545078], [cite:PMID:31409651], [cite:PMID:33243853], [cite:PMID:32179686]]. This domain collaborates with the RecA domains at the N-terminal in the formation of a RNA binding channel to allow the helicases to keep a stable grip on the RNA.

18 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (18 proteins: gene, accession, name)

• DHX15
• DHX16
• DHX29
• DHX30
• DHX32
• DHX33
• DHX34
• DHX35
• DHX36
• DHX37
• DHX38
• DHX40
• DHX57
• DHX8
• DHX9
• DQX1
• TDRD9
• YTHDC2