ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein
Also known as: dJ583P15.3, FLJ14972, GPATC6, GPATCH6, KIAA1847, MGC44880, ZC3H9, ZC3HDC9, ZGPAT_HUMAN, ZIP
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8N5A5
- Gene
- ZGPAT
- Ensembl
- ENSG00000197114
- Chromosome
- 20
- Canonical length
- 531 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Plasma membrane
OverviewNCBI Gene
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity and negative regulation of transcription by RNA polymerase II. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
531 residues, UniProt reviewed canonical sequence.
>Q8N5A5|ZGPAT
1 MDEESLESAL QTYRAQLQQV ELALGAGLDS SEQADLRQLQ GDLKELIELT EASLVSVRKS
61 SLLAALDEER PGRQEDAEYQ AFREAITEAV EAPAAARGSG SETVPKAEAG PESAAGGQEE
121 EEGEDEEELS GTKVSAPYYS SWGTLEYHNA MVVGTEEAED GSAGVRVLYL YPTHKSLKPC
181 PFFLEGKCRF KENCRFSHGQ VVSLDELRPF QDPDLSSLQA GSACLAKHQD GLWHAARITD
241 VDNGYYTVKF DSLLLREAVV EGDGILPPLR TEATESDSDS DGTGDSSYAR VVGSDAVDSA
301 QSSALCPSLA VVGSDAVDSG TCSSAFAGWE VHTRGIGSRL LTKMGYEFGK GLGRHAEGRV
361 EPIHAVVLPR GKSLDQCVET LQKQTRVGKA GTNKPPRCRG RGARPGGRPA PRNVFDFLNE
421 KLQGQAPGAL EAGAAPAGRR SKDMYHASKS AKRALSLRLF QTEEKIERTQ RDIRSIQEAL
481 ARNAGRHSVA SAQLQEKLAG AQRQLGQLRA QEAGLQQEQR KADTHKKMTE FLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZGPAT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.48
- Highest tissue expression
- 123 nTPM
Expression across tissuesHPA
Tissue
- liver: 123 nTPM
- cerebellum: 22 nTPM
- kidney: 21 nTPM
- testis: 19 nTPM
- spleen: 19 nTPM
- skin: 18 nTPM
Single-cell type
- cardiomyocytes: 31 nCPM
- choroid plexus epithelial cells: 26 nCPM
- tuft cells: 12 nCPM
- epicardial cells: 11 nCPM
- brain excitatory neurons: 9.1 nCPM
- brain inhibitory neurons: 8.9 nCPM
Immune cell
- gdT-cell: 28 nTPM
- plasmacytoid DC: 28 nTPM
- MAIT T-cell: 28 nTPM
- eosinophil: 27 nTPM
- NK-cell: 27 nTPM
- memory CD8 T-cell: 26 nTPM
Brain region
- choroid plexus: 18 nTPM
- medulla oblongata: 18 nTPM
- white matter: 17 nTPM
- cerebral cortex: 16 nTPM
- pons: 15 nTPM
- thalamus: 15 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.78
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of DNA-templated transcription
- negative regulation of epidermal growth factor-activated receptor activity
- negative regulation of transcription by RNA polymerase II
Molecular functions
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZGPAT in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZGPAT as an antibody target. Whether an autoantibody or antibody against ZGPAT could matter depends on whether native ZGPAT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZGPAT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZGPAT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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