Helicase associated domain (HA2), ratchet-like
PF21010
Definition
The helicase associated domain (HA2) has an all alpha-helical fold and consists of a N-terminal winged-helix (WH) domain ([pfam:PF04408]) and a C-terminal degenerate helical-bundle domain, referred to as the ratchet-like domain [[cite:PMID:26545078],[cite:PMID:31409651],[cite:PMID:32179686]]. These domains collaborate with the RecA domains at the N-terminal in completing an RNA binding channel to allow the helicases to keep a stable grip on the RNA PMID:32179686. This entry represents the ratchet-like domain, which may be important for RNA translocation [[cite:PMID:26545078],[cite:PMID:31409651]].
18 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...