Seroatlas · Human Serome Atlas

CTTN

Src substrate cortactin

Also known as: EMS1, SRC8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14247
Gene
CTTN
Ensembl
ENSG00000085733
Chromosome
11
Canonical length
550 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane

OverviewNCBI Gene

This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

550 residues, UniProt reviewed canonical sequence.

>Q14247|CTTN
     1  MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE
    61  NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG
   121  FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG
   181  KTEKHESQRD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT
   241  DRQDKCALGW DHQEKLQLHE SQKDYKTGFG GKFGVQSERQ DSAAVGFDYK EKLAKHESQQ
   301  DYSKGFGGKY GVQKDRMDKN ASTFEDVTQV SSAYQKTVPV EAVTSKTSNI RANFENLAKE
   361  KEQEDRRKAE AERAQRMAKE RQEQEEARRK LEEQARAKTQ TPPVSPAPQP TEERLPSSPV
   421  YEDAASFKAE LSYRGPVSGT EPEPVYSMEA ADYREASSQQ GLAYATEAVY ESAEAPGHYP
   481  AEDSTYDEYE NDLGITAVAL YDYQAAGDDE ISFDPDDIIT NIEMIDDGWW RGVCKGRYGL
   541  FPANYVELRQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTTN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
138 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 138 nTPM
  • blood vessel: 133 nTPM
  • esophagus: 128 nTPM
  • ovary: 110 nTPM
  • endometrium: 106 nTPM
  • cervix: 104 nTPM

Single-cell type

  • platelets: 346 nCPM
  • oligodendrocytes: 158 nCPM
  • renal collecting duct principal cells: 135 nCPM
  • papillary tip epithelial cells: 127 nCPM
  • renal collecting duct intercalated cells: 115 nCPM
  • proximal tubule cells: 100 nCPM

Immune cell

  • total PBMC: 6.7 nTPM
  • neutrophil: 2.1 nTPM
  • basophil: 1.2 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • medulla oblongata: 41 nTPM
  • white matter: 38 nTPM
  • midbrain: 35 nTPM
  • pons: 34 nTPM
  • thalamus: 33 nTPM
  • cerebellum: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.09
gnomAD missense Z
0.87
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTTN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTTN as an antibody target. Whether an autoantibody or antibody against CTTN could matter depends on whether native CTTN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTTN is annotated at the cell surface, where native CTTN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CTTN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTTN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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