C22orf39
Synaptic plasticity regulator PANTS
Also known as: CV039_HUMAN, MGC74441
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P5X5
- Gene
- C22orf39
- Ensembl
- ENSG00000242259
- Chromosome
- 22
- Canonical length
- 105 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Endoplasmic reticulum
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to be involved in negative regulation of long-term synaptic potentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
105 residues, UniProt reviewed canonical sequence.
>Q6P5X5|C22orf39
1 MADGSGWQPP RPCEAYRAEW KLCRSARHFL HHYYVHGERP ACEQWQRDLA SCRDWEERRN
61 AEAQQSLCES ERARVRAARK HILVWAPRQS PPPDWHLPLP QEKDELocalizationUniProt · AlphaFold · HPA
Whether an antibody against C22orf39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 90 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 90 nTPM
- tongue: 42 nTPM
- amygdala: 42 nTPM
- midbrain: 41 nTPM
- cerebral cortex: 39 nTPM
- heart muscle: 39 nTPM
Single-cell type
- megakaryocytes: 74 nCPM
- parietal cells: 58 nCPM
- late primary spermatocytes: 46 nCPM
- gastric chief cells: 36 nCPM
- hofbauer cells: 36 nCPM
- enterocytes: 33 nCPM
Immune cell
- eosinophil: 72 nTPM
- neutrophil: 43 nTPM
- plasmacytoid DC: 39 nTPM
- basophil: 37 nTPM
- T-reg: 35 nTPM
- intermediate monocyte: 34 nTPM
Brain region
- thalamus: 34 nTPM
- pons: 33 nTPM
- spinal cord: 32 nTPM
- midbrain: 31 nTPM
- amygdala: 31 nTPM
- cerebral cortex: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.2
- DepMap mean gene effect
- -0.18
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Plasticity-Associated Neural Transcript Short/Early meiotic induction protein 1-like
- Synaptic plasticity regulator PANTS-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C22orf39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C22orf39 as an antibody target. Whether an autoantibody or antibody against C22orf39 could matter depends on whether native C22orf39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C22orf39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C22orf39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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