Seroatlas · Human Serome Atlas

SNX31

Sorting nexin-31

Also known as: MGC39715, SNX31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9S9
Gene: SNX31
Ensembl: ENSG00000174226
Chromosome: 8
Canonical length: 440 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be located in cytoskeleton. Predicted to be part of protein-containing complex. Predicted to be active in early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

440 residues, UniProt reviewed canonical sequence.

>Q8N9S9|SNX31
     1  MKMHFCIPVS QQRSDALGGR YVLYSVHLDG FLFCRVRYSQ LHGWNEQLRR VFGNCLPPFP
    61  PKYYLAMTTA MADERRDQLE QYLQNVTMDP NVLRSDVFVE FLKLAQLNTF DIATKKAYLD
   121  IFLPNEQSIR IEIITSDTAE RVLEVVSHKI GLCRELLGYF GLFLIRFGKE GKLSVVKKLA
   181  DFELPYVSLG SSEVENCKVG LRKWYMAPSL DSVLMDCRVA VDLLYMQAIQ DIEKGWAKPT
   241  QAQRQKLEAF QKEDSQTKFL ELAREVRHYG YLQLDPCTCD YPESGSGAVL SVGNNEISCC
   301  ITLPDSQTQD IVFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS EDSCWQWFVI
   361  YTKQAFLLSS CLKKMISEKM VKLAAENTEM QIEVPEQSKS KKYHIQQSQQ KDYSSFLSRK
   421  SKIKIAKDDC VFGNIKEEDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 15 nTPM
esophagus: 6.1 nTPM
testis: 3.7 nTPM
tonsil: 3.4 nTPM
cerebral cortex: 2.1 nTPM
heart muscle: 1.6 nTPM

Single-cell type

respiratory basal cells: 229 nCPM
papillary tip epithelial cells: 195 nCPM
pdcs: 182 nCPM
urothelial cells: 165 nCPM
prostatic hillock cells: 161 nCPM
early spermatids: 132 nCPM

Immune cell

basophil: 0.5 nTPM
memory B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 13 nTPM
white matter: 10 nTPM
hippocampal formation: 8.6 nTPM
basal ganglia: 8.5 nTPM
amygdala: 8.3 nTPM
cerebellum: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

phosphatidylinositol binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX31 as an antibody target. Whether an autoantibody or antibody against SNX31 could matter depends on whether native SNX31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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