Seroatlas · Human Serome Atlas

NHSL3

NHS-like protein 3

Also known as: KIAA1522, NHSL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P206
Gene: NHSL3
Ensembl: ENSG00000162522
Chromosome: 1
Canonical length: 1035 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to be involved in cell differentiation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1035 residues, UniProt reviewed canonical sequence.

>Q9P206|NHSL3
     1  MVVFVGRRLP ALLGLFKKKG SAKAENDKHL SVGPGQGPGS AVDEHQDNVF FPSGRPPHLE
    61  ELHTQAQEGL RSLQHQEKQK LNKGGWDHGD TQSIQSSRTG PDEDNISFCS QTTSYVAESS
   121  TAEDALSIRS EMIQRKGSTF RPHDSFPKSG KSGRRRRERR STVLGLPQHV QKELGLRNER
   181  EAPGTPRAPG ARDAVRIPTV DGRPRGTSGM GARVSLQALE AEAEAGAETE AMLQRHIDRV
   241  YRDDTFVGRS TGTRAPPLTR PMSLAVPGLT GGAGPAEPLS PAMSISPQAT YLSKLIPHAV
   301  LPPTVDVVAL GRCSLRTLSR CSLHSASPAS VRSLGRFSSV SSPQPRSRHP SSSSDTWSHS
   361  QSSDTIVSDG STLSSKGGSE GQPESSTASN SVVPPPQGGS GRGSPSGGST AEASDTLSIR
   421  SSGQLSGRSV SLRKLKRPPP PPRRTHSLHQ RGLAVPDGPL GLPPKPERKQ QPQLPRPPTT
   481  GGSEGAGAAP CPPNPANSWV PGLSPGGSRR PPRSPERTLS PSSGYSSQSG TPTLPPKGLA
   541  GPPASPGKAQ PPKPERVTSL RSPGASVSSS LTSLCSSSSD PAPSDRSGPQ ILTPLGDRFV
   601  IPPHPKVPAP FSPPPSKPRS PNPAAPALAA PAVVPGPVST TDASPQSPPT PQTTLTPLQE
   661  SPVISKDQSP PPSPPPSYHP PPPPTKKPEV VVEAPSASET AEEPLQDPNW PPPPPPAPEE
   721  QDLSMADFPP PEEAFFSVAS PEPAGPSGSP ELVSSPAASS SSATALQIQP PGSPDPPPAP
   781  PAPAPASSAP GHVAKLPQKE PVGCSKGGGP PREDVGAPLV TPSLLQMVRL RSVGAPGGAP
   841  TPALGPSAPQ KPLRRALSGR ASPVPAPSSG LHAAVRLKAC SLAASEGLSS AQPNGPPEAE
   901  PRPPQSPAST ASFIFSKGSR KLQLERPVSP ETQADLQRNL VAELRSISEQ RPPQAPKKSP
   961  KAPPPVARKP SVGVPPPASP SYPRAEPLTA PPTNGLPHTQ DRTKRELAEN GGVLQLVGPE
  1021  EKMGLPGSDS QKELA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NHSL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 88 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 88 nTPM
esophagus: 74 nTPM
skin: 71 nTPM
pancreas: 68 nTPM
salivary gland: 64 nTPM
stomach: 59 nTPM

Single-cell type

salivary duct cells: 164 nCPM
foveolar cells: 160 nCPM
colonocytes: 159 nCPM
prostatic hillock cells: 152 nCPM
prostatic club cells: 137 nCPM
urothelial cells: 136 nCPM

Immune cell

myeloid DC: 0.3 nTPM
classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 61 nTPM
cerebral cortex: 34 nTPM
amygdala: 34 nTPM
basal ganglia: 24 nTPM
hippocampal formation: 23 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.03
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell differentiation

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NHSL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NHSL3 as an antibody target. Whether an autoantibody or antibody against NHSL3 could matter depends on whether native NHSL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NHSL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NHSL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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