IMD/I-BAR domain
IPR013606
Definition
The I-BAR domain (also known as IMD domain, IRSp53 and MIM homology domain) is a BAR-like domain of approximately 250 amino acids found at the N-terminal in the IRSp53 (insulin receptor tyrosine kinase substrate p53) and in the evolutionarily related IRSp53/MIM family. The BAR domain forms an anti-parallel all-helical dimer, with a curved (banana-like) shape, that promotes membrane tubulation. The BAR domain containing proteins can be classified into three types: BAR, F-BAR and I-BAR. BAR and F-BAR proteins generate positive membrane curvature, while I-BAR proteins induce negative curvature [[cite:PMID:21743456], [cite:PMID:21093245]]. The I-BAR domain containing proteins include: Vertebrate MIM (missing in metastasis, also known as Protein MTSS 1), an actin-binding scaffold protein that may be involved in cancer metastasis. Vertebrate ABBA, a MIM-related protein (also known as Protein MTSS 2). Vertebrate insulin receptor tyrosine kinase substrate p53 (IRSp53, also known as BAR/IMD domain-containing adapter protein 2), a multifunctional adaptor protein that links Rac1 with a Wiskott-Aldrich syndrome family verprolin-homologous protein 2 (WAVE2) to induce lamellipodia or Cdc42 with Mena to induce filopodia PMID:14980512. Vertebrate IRTKS (also known as BAR/IMD domain-containing adapter protein 2-like 1), which plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection [[cite:PMID:22921828], [cite:PMID:17430976]]. Vertebrate Pinkbar (also known as BAR/IMD domain-containing adapter protein 2-like 2), which induces the formation of planar or gently curved membrane structures PMID:21743456. Caenorhabditis elegans M04F3.5 protein. The vertebrate I-BAR family is divided into two major groups: the IRSp53/IRTKS/Pinkbar subfamily and the MIM/ABBA subfamily. The putative invertebrate homologues are positioned between them. The IRSp53/IRTKS/Pinkbar subfamily members contain a SH3 domain, and the MIM/ABBA subfamily proteins contain a WH2 (WASP-homology 2) domain. The vertebrate SH3-containing subfamily is further divided into three groups according to the presence or absence of the WWB and the half-CRIB motif [[cite:PMID:14752106], [cite:PMID:17497115]]. The BAR domain binds phosphoinositide-rich vesicles with high affinity and does not display strong actin filament binding/bundling activity [[cite:PMID:21093245], [cite:PMID:17371834]].
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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