Seroatlas · Protein domains
Reprolysin (M12B) family zinc metalloprotease
PF01421
Definition
The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as [swissprot:P78325], and fertilin [swissprot:Q28472]. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.
38 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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