Seroatlas · Human Serome Atlas

ADAM7

Disintegrin and metalloproteinase domain-containing protein 7

Also known as: ADAM7_HUMAN, EAPI, GP-83

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H2U9
Gene: ADAM7
Ensembl: ENSG00000069206
Chromosome: 8
Canonical length: 754 aa
Protein class: Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

754 residues, UniProt reviewed canonical sequence.

>Q9H2U9|ADAM7
     1  MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL
    61  YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA
   121  ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV
   181  PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL
   241  NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV
   301  QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD
   361  SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP
   421  AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC
   481  PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK
   541  NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD
   601  IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC
   661  EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE
   721  QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 3,519 nTPM

Expression across tissuesHPA

Tissue

epididymis: 3,519 nTPM
seminal vesicle: 15 nTPM
testis: 2.1 nTPM
pancreas: 0.5 nTPM
kidney: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

epididymal principal cells: 3,360 nCPM
early spermatids: 469 nCPM
late primary spermatocytes: 450 nCPM
epididymal basal cells: 100 nCPM
retinal ganglion cells: 43 nCPM
late spermatids: 31 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 4 nTPM
white matter: 3.2 nTPM
pons: 3.1 nTPM
medulla oblongata: 2.1 nTPM
basal ganglia: 1.3 nTPM
hippocampal formation: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: -0.51
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

metalloendopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADAM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAM7 as an antibody target. Whether an autoantibody or antibody against ADAM7 could matter depends on whether native ADAM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAM7 is annotated at the cell surface, where native ADAM7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADAM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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