Seroatlas · Human Serome Atlas

ADAMTS14

A disintegrin and metalloproteinase with thrombospondin motifs 14

Also known as: ATS14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WXS8
Gene
ADAMTS14
Ensembl
ENSG00000138316
Chromosome
10
Canonical length
1223 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted secreted proteins
Subcellular location
Golgi apparatus,Vesicles
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

1223 residues, UniProt reviewed canonical sequence.

>Q8WXS8|ADAMTS14
     1  MAPLRALLSY LLPLHCALCA AAGSRTPELH LSGKLSDYGV TVPCSTDFRG RFLSHVVSGP
    61  AAASAGSMVV DTPPTLPRHS SHLRVARSPL HPGGTLWPGR VGRHSLYFNV TVFGKELHLR
   121  LRPNRRLVVP GSSVEWQEDF RELFRQPLRQ ECVYTGGVTG MPGAAVAISN CDGLAGLIRT
   181  DSTDFFIEPL ERGQQEKEAS GRTHVVYRRE AVQQEWAEPD GDLHNEAFGL GDLPNLLGLV
   241  GDQLGDTERK RRHAKPGSYS IEVLLVVDDS VVRFHGKEHV QNYVLTLMNI VDEIYHDESL
   301  GVHINIALVR LIMVGYRQSL SLIERGNPSR SLEQVCRWAH SQQRQDPSHA EHHDHVVFLT
   361  RQDFGPSGYA PVTGMCHPLR SCALNHEDGF SSAFVIAHET GHVLGMEHDG QGNGCADETS
   421  LGSVMAPLVQ AAFHRFHWSR CSKLELSRYL PSYDCLLDDP FDPAWPQPPE LPGINYSMDE
   481  QCRFDFGSGY QTCLAFRTFE PCKQLWCSHP DNPYFCKTKK GPPLDGTECA PGKWCFKGHC
   541  IWKSPEQTYG QDGGWSSWTK FGSCSRSCGG GVRSRSRSCN NPSPAYGGRL CLGPMFEYQV
   601  CNSEECPGTY EDFRAQQCAK RNSYYVHQNA KHSWVPYEPD DDAQKCELIC QSADTGDVVF
   661  MNQVVHDGTR CSYRDPYSVC ARGECVPVGC DKEVGSMKAD DKCGVCGGDN SHCRTVKGTL
   721  GKASKQAGAL KLVQIPAGAR HIQIEALEKS PHRIVVKNQV TGSFILNPKG KEATSRTFTA
   781  MGLEWEDAVE DAKESLKTSG PLPEAIAILA LPPTEGGPRS SLAYKYVIHE DLLPLIGSNN
   841  VLLEEMDTYE WALKSWAPCS KACGGGIQFT KYGCRRRRDH HMVQRHLCDH KKRPKPIRRR
   901  CNQHPCSQPV WVTEEWGACS RSCGKLGVQT RGIQCLLPLS NGTHKVMPAK ACAGDRPEAR
   961  RPCLRVPCPA QWRLGAWSQC SATCGEGIQQ RQVVCRTNAN SLGHCEGDRP DTVQVCSLPA
  1021  CGGNHQNSTV RADVWELGTP EGQWVPQSEP LHPINKISST EPCTGDRSVF CQMEVLDRYC
  1081  SIPGYHRLCC VSCIKKASGP NPGPDPGPTS LPPFSTPGSP LPGPQDPADA AEPPGKPTGS
  1141  EDHQHGRATQ LPGALDTSSP GTQHPFAPET PIPGASWSIS PTTPGGLPWG WTQTPTPVPE
  1201  DKGQPGEDLR HPGTSLPAAS PVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTS14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 7.1 nTPM
  • gallbladder: 6.3 nTPM
  • basal ganglia: 4.3 nTPM
  • hippocampal formation: 3.6 nTPM
  • appendix: 3 nTPM
  • small intestine: 3 nTPM

Single-cell type

  • oligodendrocytes: 29 nCPM
  • myosatellite cells: 24 nCPM
  • epididymal basal cells: 13 nCPM
  • megakaryocyte-erythroid progenitors: 13 nCPM
  • ocular epithelial cells: 13 nCPM
  • mast cells: 12 nCPM

Immune cell

  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 23 nTPM
  • white matter: 20 nTPM
  • cerebral cortex: 14 nTPM
  • basal ganglia: 12 nTPM
  • midbrain: 8.3 nTPM
  • hypothalamus: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.29
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAMTS14 as an antibody target. Whether an autoantibody or antibody against ADAMTS14 could matter depends on whether native ADAMTS14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAMTS14 is annotated as secreted, so native ADAMTS14 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADAMTS14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADAMTS14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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