Seroatlas · Human Serome Atlas

ADAM8

Disintegrin and metalloproteinase domain-containing protein 8

Also known as: ADAM8_HUMAN, CD156, CD156A, MS2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P78325
Gene
ADAM8
Ensembl
ENSG00000151651
Chromosome
10
Canonical length
824 aa
Protein class
CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

Canonical amino-acid sequenceUniProt

824 residues, UniProt reviewed canonical sequence.

>P78325|ADAM8
     1  MRGLGLWLLG AMMLPAIAPS RPWALMEQYE VVLPWRLPGP RVRRALPSHL GLHPERVSYV
    61  LGATGHNFTL HLRKNRDLLG SGYTETYTAA NGSEVTEQPR GQDHCFYQGH VEGYPDSAAS
   121  LSTCAGLRGF FQVGSDLHLI EPLDEGGEGG RHAVYQAEHL LQTAGTCGVS DDSLGSLLGP
   181  RTAAVFRPRP GDSLPSRETR YVELYVVVDN AEFQMLGSEA AVRHRVLEVV NHVDKLYQKL
   241  NFRVVLVGLE IWNSQDRFHV SPDPSVTLEN LLTWQARQRT RRHLHDNVQL ITGVDFTGTT
   301  VGFARVSAMC SHSSGAVNQD HSKNPVGVAC TMAHEMGHNL GMDHDENVQG CRCQERFEAG
   361  RCIMAGSIGS SFPRMFSDCS QAYLESFLER PQSVCLANAP DLSHLVGGPV CGNLFVERGE
   421  QCDCGPPEDC RNRCCNSTTC QLAEGAQCAH GTCCQECKVK PAGELCRPKK DMCDLEEFCD
   481  GRHPECPEDA FQENGTPCSG GYCYNGACPT LAQQCQAFWG PGGQAAEESC FSYDILPGCK
   541  ASRYRADMCG VLQCKGGQQP LGRAICIVDV CHALTTEDGT AYEPVPEGTR CGPEKVCWKG
   601  RCQDLHVYRS SNCSAQCHNH GVCNHKQECH CHAGWAPPHC AKLLTEVHAA SGSLPVFVVV
   661  VLVLLAVVLV TLAGIIVYRK ARSRILSRNV APKTTMGRSN PLFHQAASRV PAKGGAPAPS
   721  RGPQELVPTT HPGQPARHPA SSVALKRPPP APPVTVSSPP FPVPVYTRQA PKQVIKPTFA
   781  PPVPPVKPGA GAANPGPAEG AVGPKVALKP PIQRKQGAGA PTAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 65 nTPM
  • spleen: 47 nTPM
  • lung: 21 nTPM
  • appendix: 21 nTPM
  • urinary bladder: 11 nTPM
  • lymph node: 11 nTPM

Single-cell type

  • neutrophils: 326 nCPM
  • extravillous trophoblasts: 137 nCPM
  • cdc: 77 nCPM
  • nk-cells: 54 nCPM
  • mast cells: 47 nCPM
  • neutrophil progenitors: 44 nCPM

Immune cell

  • eosinophil: 259 nTPM
  • neutrophil: 140 nTPM
  • basophil: 108 nTPM
  • myeloid DC: 37 nTPM
  • total PBMC: 25 nTPM
  • classical monocyte: 25 nTPM

Brain region

  • cerebral cortex: 44 nTPM
  • thalamus: 13 nTPM
  • pons: 9.4 nTPM
  • medulla oblongata: 7 nTPM
  • white matter: 6.9 nTPM
  • basal ganglia: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADAM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • FST3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAM8 as an antibody target. Whether an autoantibody or antibody against ADAM8 could matter depends on whether native ADAM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAM8 is annotated at the cell surface, where native ADAM8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADAM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADAM8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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