Seroatlas · Human Serome Atlas

ADAM33

Disintegrin and metalloproteinase domain-containing protein 33

Also known as: ADA33_HUMAN, C20orf153, dJ964F7.1, DKFZp434K0521

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZ11
Gene: ADAM33
Ensembl: ENSG00000149451
Chromosome: 20
Canonical length: 813 aa
Protein class: Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

813 residues, UniProt reviewed canonical sequence.

>Q9BZ11|ADAM33
     1  MGWRPRRARG TPLLLLLLLL LLWPVPGAGV LQGHIPGQPV TPHWVLDGQP WRTVSLEEPV
    61  SKPDMGLVAL EAEGQELLLE LEKNHRLLAP GYIETHYGPD GQPVVLAPNH TDHCHYQGRV
   121  RGFPDSWVVL CTCSGMSGLI TLSRNASYYL RPWPPRGSKD FSTHEIFRME QLLTWKGTCG
   181  HRDPGNKAGM TSLPGGPQSR GRREARRTRK YLELYIVADH TLFLTRHRNL NHTKQRLLEV
   241  ANYVDQLLRT LDIQVALTGL EVWTERDRSR VTQDANATLW AFLQWRRGLW AQRPHDSAQL
   301  LTGRAFQGAT VGLAPVEGMC RAESSGGVST DHSELPIGAA ATMAHEIGHS LGLSHDPDGC
   361  CVEAAAESGG CVMAAATGHP FPRVFSACSR RQLRAFFRKG GGACLSNAPD PGLPVPPALC
   421  GNGFVEAGEE CDCGPGQECR DLCCFAHNCS LRPGAQCAHG DCCVRCLLKP AGALCRQAMG
   481  DCDLPEFCTG TSSHCPPDVY LLDGSPCARG SGYCWDGACP TLEQQCQQLW GPGSHPAPEA
   541  CFQVVNSAGD AHGNCGQDSE GHFLPCAGRD ALCGKLQCQG GKPSLLAPHM VPVDSTVHLD
   601  GQEVTCRGAL ALPSAQLDLL GLGLVEPGTQ CGPRMVCQSR RCRKNAFQEL QRCLTACHSH
   661  GVCNSNHNCH CAPGWAPPFC DKPGFGGSMD SGPVQAENHD TFLLAMLLSV LLPLLPGAGL
   721  AWCCYRLPGA HLQRCSWGCR RDPACSGPKD GPHRDHPLGG VHPMELGPTA TGQPWPLDPE
   781  NSHEPSSHPE KPLPAVSPDP QADQVQMPRS CLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 121 nTPM

Expression across tissuesHPA

Tissue

cervix: 121 nTPM
colon: 96 nTPM
endometrium: 96 nTPM
vagina: 94 nTPM
urinary bladder: 82 nTPM
fallopian tube: 70 nTPM

Single-cell type

fibro-adipogenic progenitors: 125 nCPM
sertoli cells: 103 nCPM
smooth muscle cells: 68 nCPM
bergmann glia: 63 nCPM
fibroblasts: 60 nCPM
leydig cells: 56 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 20 nTPM
medulla oblongata: 13 nTPM
hypothalamus: 9 nTPM
cerebral cortex: 8.5 nTPM
choroid plexus: 7.2 nTPM
basal ganglia: 7.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAM33.

Disease | AllUniProt

Conditions ADAM33 is implicated in, by any mechanism.

Asthma (ASTHMA) MIM:600807

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAM33 as an antibody target. Whether an autoantibody or antibody against ADAM33 could matter depends on whether native ADAM33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAM33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADAM33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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