ADAMDEC1
ADAM DEC1
Also known as: ADEC1_HUMAN, M12.219
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15204
- Gene
- ADAMDEC1
- Ensembl
- ENSG00000134028
- Chromosome
- 8
- Canonical length
- 470 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in other tissues
OverviewNCBI Gene
This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during dendritic cells maturation. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
470 residues, UniProt reviewed canonical sequence.
>O15204|ADAMDEC1
1 MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL HILHKREIKN
61 NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP DYTETLYSPR GEEITTKPEN
121 MEHCYYKGNI LNEKNSVASI STCDGLRGYF THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ
181 DPANHTCGVK STDGKQGPIR ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL
241 IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK
301 KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM SHELGHVLGM
361 PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT
421 PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL TCKLKPGTDC GGDAPNHTTELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ADAMDEC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 400 nTPM
Expression across tissuesHPA
Tissue
- small intestine: 400 nTPM
- rectum: 293 nTPM
- colon: 202 nTPM
- duodenum: 178 nTPM
- lymph node: 69 nTPM
- appendix: 49 nTPM
Single-cell type
- macrophages: 55 nCPM
- monocytes: 18 nCPM
- cdc: 13 nCPM
- b-cells: 10 nCPM
- fibroblasts: 2.9 nCPM
- plasma cells: 2.5 nCPM
Immune cell
- eosinophil: 1.9 nTPM
- memory B-cell: 1.1 nTPM
- intermediate monocyte: 0.8 nTPM
- classical monocyte: 0.7 nTPM
- naive B-cell: 0.5 nTPM
- non-classical monocyte: 0.3 nTPM
Brain region
- cerebral cortex: 1.3 nTPM
- thalamus: 1.2 nTPM
- pons: 1 nTPM
- medulla oblongata: 0.7 nTPM
- white matter: 0.7 nTPM
- hippocampal formation: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.29
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.09
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ADAMDEC1 as an antibody target. Whether an autoantibody or antibody against ADAMDEC1 could matter depends on whether native ADAMDEC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ADAMDEC1 is annotated as secreted, so native ADAMDEC1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ADAMDEC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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