Seroatlas · Human Serome Atlas

ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1

Also known as: ATS1_HUMAN, C3-C5, KIAA1346, METH1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UHI8
Gene: ADAMTS1
Ensembl: ENSG00000154734
Chromosome: 21
Canonical length: 967 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transporters
Subcellular location: Plasma membrane
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

967 residues, UniProt reviewed canonical sequence.

>Q9UHI8|ADAMTS1
     1  MQRAVPEGFG RRKLGSDMGN AERAPGSRSF GPVPTLLLLA AALLAVSDAL GRPSEEDEEL
    61  VVPELERAPG HGTTRLRLHA FDQQLDLELR PDSSFLAPGF TLQNVGRKSG SETPLPETDL
   121  AHCFYSGTVN GDPSSAAALS LCEGVRGAFY LLGEAYFIQP LPAASERLAT AAPGEKPPAP
   181  LQFHLLRRNR QGDVGGTCGV VDDEPRPTGK AETEDEDEGT EGEDEGAQWS PQDPALQGVG
   241  QPTGTGSIRK KRFVSSHRYV ETMLVADQSM AEFHGSGLKH YLLTLFSVAA RLYKHPSIRN
   301  SVSLVVVKIL VIHDEQKGPE VTSNAALTLR NFCNWQKQHN PPSDRDAEHY DTAILFTRQD
   361  LCGSQTCDTL GMADVGTVCD PSRSCSVIED DGLQAAFTTA HELGHVFNMP HDDAKQCASL
   421  NGVNQDSHMM ASMLSNLDHS QPWSPCSAYM ITSFLDNGHG ECLMDKPQNP IQLPGDLPGT
   481  SYDANRQCQF TFGEDSKHCP DAASTCSTLW CTGTSGGVLV CQTKHFPWAD GTSCGEGKWC
   541  INGKCVNKTD RKHFDTPFHG SWGMWGPWGD CSRTCGGGVQ YTMRECDNPV PKNGGKYCEG
   601  KRVRYRSCNL EDCPDNNGKT FREEQCEAHN EFSKASFGSG PAVEWIPKYA GVSPKDRCKL
   661  ICQAKGIGYF FVLQPKVVDG TPCSPDSTSV CVQGQCVKAG CDRIIDSKKK FDKCGVCGGN
   721  GSTCKKISGS VTSAKPGYHD IITIPTGATN IEVKQRNQRG SRNNGSFLAI KAADGTYILN
   781  GDYTLSTLEQ DIMYKGVVLR YSGSSAALER IRSFSPLKEP LTIQVLTVGN ALRPKIKYTY
   841  FVKKKKESFN AIPTFSAWVI EEWGECSKSC ELGWQRRLVE CRDINGQPAS ECAKEVKPAS
   901  TRPCADHPCP QWQLGEWSSC SKTCGKGYKK RSLKCLSHDG GVLSHESCDP LKKPKHFIDF
   961  CTMAECS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 368 nTPM

Expression across tissuesHPA

Tissue

ovary: 368 nTPM
blood vessel: 292 nTPM
adipose tissue: 274 nTPM
placenta: 230 nTPM
fallopian tube: 205 nTPM
smooth muscle: 152 nTPM

Single-cell type

vascular smooth muscle cells: 929 nCPM
pericytes: 700 nCPM
vascular endothelial cells: 389 nCPM
smooth muscle cells: 357 nCPM
extravillous trophoblasts: 340 nCPM
fibroblasts: 291 nCPM

Immune cell

NK-cell: 6.6 nTPM
gdT-cell: 4.5 nTPM
total PBMC: 0.8 nTPM
naive CD8 T-cell: 0.7 nTPM
MAIT T-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM

Brain region

white matter: 38 nTPM
cerebral cortex: 33 nTPM
thalamus: 31 nTPM
pons: 28 nTPM
spinal cord: 28 nTPM
medulla oblongata: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAMTS1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 162 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Premature ovarian failure

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.72
gnomAD missense Z: 0.67
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAMTS1 as an antibody target. Whether an autoantibody or antibody against ADAMTS1 could matter depends on whether native ADAMTS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAMTS1 is annotated as secreted, so native ADAMTS1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADAMTS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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