Seroatlas · Human Serome Atlas

ADAMTS19

A disintegrin and metalloproteinase with thrombospondin motifs 19

Also known as: ATS19_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE59
Gene: ADAMTS19
Canonical length: 1213 aa
Protein class: Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for ADAMTS19 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1213 residues, UniProt reviewed canonical sequence.

>Q8TE59|ADAMTS19
     1  MGKNREMRLT HICCCCLLYQ LGFLSNGIVS ELQFAPDREE WEVVFPALWR REPVDPAGGS
    61  GGSADPGWVR GVGGGGSARA QAAGSSREVR SVAPVPLEEP VEGRSESRLR PPPPSEGEED
   121  EELESQELPR GSSGAAALSP GAPASWQPPP PPQPPPSPPP AQHAEPDGDE VLLRIPAFSR
   181  DLYLLLRRDG RFLAPRFAVE QRPNPGPGPT GAASAPQPPA PPDAGCFYTG AVLRHPGSLA
   241  SFSTCGGGLM GFIQLNEDFI FIEPLNDTMA ITGHPHRVYR QKRSMEEKVT EKSALHSHYC
   301  GIISDKGRPR SRKIAESGRG KRYSYKLPQE YNIETVVVAD PAMVSYHGAD AARRFILTIL
   361  NMVFNLFQHK SLSVQVNLRV IKLILLHETP PELYIGHHGE KMLESFCKWQ HEEFGKKNDI
   421  HLEMSTNWGE DMTSVDAAIL ITRKDFCVHK DEPCDTVGIA YLSGMCSEKR KCIIAEDNGL
   481  NLAFTIAHEM GHNMGINHDN DHPSCADGLH IMSGEWIKGQ NLGDVSWSRC SKEDLERFLR
   541  SKASNCLLQT NPQSVNSVMV PSKLPGMTYT ADEQCQILFG PLASFCQEMQ HVICTGLWCK
   601  VEGEKECRTK LDPPMDGTDC DLGKWCKAGE CTSRTSAPEH LAGEWSLWSP CSRTCSAGIS
   661  SRERKCPGLD SEARDCNGPR KQYRICENPP CPAGLPGFRD WQCQAYSVRT SSPKHILQWQ
   721  AVLDEEKPCA LFCSPVGKEQ PILLSEKVMD GTSCGYQGLD ICANGRCQKV GCDGLLGSLA
   781  REDHCGVCNG NGKSCKIIKG DFNHTRGAGY VEVLVIPAGA RRIKVVEEKP AHSYLALRDA
   841  GKQSINSDWK IEHSGAFNLA GTTVHYVRRG LWEKISAKGP TTAPLHLLVL LFQDQNYGLH
   901  YEYTIPSDPL PENQSSKAPE PLFMWTHTSW EDCDATCGGG ERKTTVSCTK IMSKNISIVD
   961  NEKCKYLTKP EPQIRKCNEQ PCQTRWMMTE WTPCSRTCGK GMQSRQVACT QQLSNGTLIR
  1021  ARERDCIGPK PASAQRCEGQ DCMTVWEAGV WSECSVKCGK GIRHRTVRCT NPRKKCVLST
  1081  RPREAEDCED YSKCYVWRMG DWSKCSITCG KGMQSRVIQC MHKITGRHGN ECFSSEKPAA
  1141  YRPCHLQPCN EKINVNTITS PRLAALTFKC LGDQWPVYCR VIREKNLCQD MRWYQRCCET
  1201  CRDFYAQKLQ QKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTS19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 9.5 nTPM

Expression across tissuesHPA

Tissue

cervix: 9.5 nTPM
endometrium: 9.2 nTPM
smooth muscle: 5.5 nTPM
placenta: 3.5 nTPM
fallopian tube: 2.1 nTPM
basal ganglia: 1.4 nTPM

Single-cell type

podocytes: 1,207 nCPM
adrenal medulla cells: 394 nCPM
cytotrophoblasts: 256 nCPM
brain inhibitory neurons: 222 nCPM
myonuclei: 171 nCPM
endometrial stromal cells: 139 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 9.4 nTPM
cerebral cortex: 7.3 nTPM
hippocampal formation: 3.8 nTPM
white matter: 3.6 nTPM
midbrain: 3.5 nTPM
thalamus: 2.8 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAMTS19.

Disease | AllUniProt

Conditions ADAMTS19 is implicated in, by any mechanism.

Cardiac valvular dysplasia 2 (CVDP2) MIM:620067

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 217 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cardiac valvular dysplasia 2
ADAMTS19-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 2.1
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular matrix

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAMTS19 as an antibody target. Whether an autoantibody or antibody against ADAMTS19 could matter depends on whether native ADAMTS19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAMTS19 is annotated as secreted, so native ADAMTS19 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADAMTS19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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