ADAM9

Protein identityUniProt · HPA

UniProt accession

Q13443

Gene

ADAM9

Ensembl

ENSG00000168615

Chromosome

8

Canonical length

819 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Subcellular location

Endoplasmic reticulum,Vesicles

Secretome location

Secreted - unknown location

OverviewNCBI Gene

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

819 residues, UniProt reviewed canonical sequence.

>Q13443|ADAM9
     1  MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR
    61  PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV
   121  EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK
   181  DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI
   241  LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS
   301  AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG
   361  RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK
   421  LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC
   481  DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF
   541  IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC
   601  WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK
   661  NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR
   721  DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA
   781  KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

53 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAM9.

Disease | AllUniProt

Conditions ADAM9 is implicated in, by any mechanism.

• Cone-rod dystrophy 9 (CORD9) MIM:612775

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 594 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cone-rod dystrophy 9
• Cone-rod dystrophy
• Retinal dystrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.03

gnomAD missense Z

1.9

DepMap mean gene effect

-0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid precursor protein catabolic process
• cell adhesion
• cell adhesion mediated by integrin
• cell migration
• cell-cell adhesion mediated by integrin
• cell-matrix adhesion
• cellular response to lipopolysaccharide
• integrin-mediated signaling pathway
• keratinocyte differentiation
• membrane protein ectodomain proteolysis
• membrane protein intracellular domain proteolysis
• monocyte activation
• positive regulation of cell adhesion mediated by integrin
• positive regulation of cell migration
• positive regulation of keratinocyte migration
• positive regulation of macrophage fusion
• positive regulation of MAPK cascade
• positive regulation of membrane protein ectodomain proteolysis
• positive regulation of protein secretion
• protein processing
• response to calcium ion
• response to glucocorticoid
• response to hydrogen peroxide
• response to manganese ion
• response to tumor necrosis factor
• transforming growth factor beta receptor signaling pathway

Molecular functions

• collagen binding
• integrin binding
• laminin binding
• metal ion binding
• metalloendopeptidase activity
• metalloendopeptidase activity involved in amyloid precursor protein catabolic process
• metallopeptidase activity
• protein kinase C binding
• SH3 domain binding

Cellular components

• cell surface
• external side of plasma membrane
• extracellular exosome
• extracellular space
• focal adhesion
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Peptidase M12B, ADAM/reprolysin
• Disintegrin domain
• Peptidase M12B, propeptide
• ADAM, cysteine-rich domain
• Disintegrin, conserved site
• Metallopeptidase, catalytic domain superfamily
• Reprolysin domain, adamalysin-type
• Disintegrin domain superfamily
• Disintegrin
• Reprolysin (M12B) family zinc metalloprotease
• Reprolysin family propeptide
• ADAM cysteine-rich

KeywordsUniProt

• Cell membrane
• Cone-rod dystrophy
• Disulfide bond
• Glycoprotein
• Hydrolase
• Membrane
• Metal-binding
• Metalloprotease
• Phosphoprotein
• Protease
• Secreted
• Signal
• Transmembrane
• Transmembrane helix
• Zinc

InteractionsUniProt · HPA

Protein binding partners of ADAM9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ITGA6
• SH3GL2
• MAD2L2
• SNX9