Seroatlas · Human Serome Atlas

ADAMTS10

A disintegrin and metalloproteinase with thrombospondin motifs 10

Also known as: ADAM-TS10, ATS10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H324
Gene: ADAMTS10
Ensembl: ENSG00000142303
Chromosome: 19
Canonical length: 1103 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1103 residues, UniProt reviewed canonical sequence.

>Q9H324|ADAMTS10
     1  MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN GALLAFSPPP
    61  PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG HVSVEYWTRE GLAWQRAARP
   121  HCLYAGHLQG QASTSHVAIS TCGGLHGLIV ADEEEYLIEP LHGGPKGSRS PEESGPHVVY
   181  KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY
   241  VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT
   301  LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT
   361  LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM NHDGVGNSCG ARGQDPAKLM
   421  AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR
   481  FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG
   541  SRPEGVDGAW GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD
   601  CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD
   661  GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPASPGAG
   721  YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ
   781  GPDQVQSLEA LGPINASLIV MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ
   841  CAGGSQVQAV ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC
   901  DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA LDWSECTPSC
   961  GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR RCPPARWVAG EWGECSAQCG
  1021  VGQRQRSVRC TSHTGQASHE CTEALRPPTT QQCEAKCDSP TPGDGPEECK DVNKVAYCPL
  1081  VLKFQFCSRA YFRQMCCKTC HGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAMTS10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 20 nTPM
adipose tissue: 14 nTPM
cervix: 11 nTPM
cerebral cortex: 11 nTPM
endometrium: 10 nTPM
fallopian tube: 9.3 nTPM

Single-cell type

myosatellite cells: 186 nCPM
microglia: 69 nCPM
adipocytes: 56 nCPM
hepatic stellate cells: 45 nCPM
vascular smooth muscle cells: 45 nCPM
fibro-adipogenic progenitors: 42 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 14 nTPM
hypothalamus: 12 nTPM
medulla oblongata: 8.3 nTPM
basal ganglia: 8.2 nTPM
amygdala: 8.1 nTPM
midbrain: 7.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADAMTS10.

Disease | AllUniProt

Conditions ADAMTS10 is implicated in, by any mechanism.

Weill-Marchesani syndrome 1 (WMS1) MIM:277600

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 1,096 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Weill-Marchesani syndrome 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.84
gnomAD missense Z: 3.63
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADAMTS10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FBN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAMTS10 as an antibody target. Whether an autoantibody or antibody against ADAMTS10 could matter depends on whether native ADAMTS10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAMTS10 is annotated as secreted, so native ADAMTS10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADAMTS10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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