Seroatlas · Human Serome Atlas

ADAM28

Disintegrin and metalloproteinase domain-containing protein 28

Also known as: ADA28_HUMAN, ADAM23, eMDCII, MDC-Lm, MDC-Ls

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKQ2
Gene
ADAM28
Ensembl
ENSG00000042980
Chromosome
8
Canonical length
775 aa
Protein class
Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters
Subcellular location
Plasma membrane,Mitochondria
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

775 residues, UniProt reviewed canonical sequence.

>Q9UKQ2|ADAM28
     1  MLQGLLPVSL LLSVAVSAIK ELPGVKKYEV VYPIRLHPLH KREAKEPEQQ EQFETELKYK
    61  MTINGKIAVL YLKKNKNLLA PGYTETYYNS TGKEITTSPQ IMDDCYYQGH ILNEKVSDAS
   121  ISTCRGLRGY FSQGDQRYFI EPLSPIHRDG QEHALFKYNP DEKNYDSTCG MDGVLWAHDL
   181  QQNIALPATK LVKLKDRKVQ EHEKYIEYYL VLDNGEFKRY NENQDEIRKR VFEMANYVNM
   241  LYKKLNTHVA LVGMEIWTDK DKIKITPNAS FTLENFSKWR GSVLSRRKRH DIAQLITATE
   301  LAGTTVGLAF MSTMCSPYSV GVVQDHSDNL LRVAGTMAHE MGHNFGMFHD DYSCKCPSTI
   361  CVMDKALSFY IPTDFSSCSR LSYDKFFEDK LSNCLFNAPL PTDIISTPIC GNQLVEMGED
   421  CDCGTSEECT NICCDAKTCK IKATFQCALG ECCEKCQFKK AGMVCRPAKD ECDLPEMCNG
   481  KSGNCPDDRF QVNGFPCHHG KGHCLMGTCP TLQEQCTELW GPGTEVADKS CYNRNEGGSK
   541  YGYCRRVDDT LIPCKANDTM CGKLFCQGGS DNLPWKGRIV TFLTCKTFDP EDTSQEIGMV
   601  ANGTKCGDNK VCINAECVDI EKAYKSTNCS SKCKGHAVCD HELQCQCEEG WIPPDCDDSS
   661  VVFHFSIVVG VLFPMAVIFV VVAMVIRHQS SREKQKKDQR PLSTTGTRPH KQKRKPQMVK
   721  AVQPQEMSQM KPHVYDLPVE GNEPPASFHK DTNALPPTVF KDNPVSTPKD SNPKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADAM28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
337 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 337 nTPM
  • stomach: 104 nTPM
  • gallbladder: 38 nTPM
  • tonsil: 30 nTPM
  • lymph node: 25 nTPM
  • small intestine: 23 nTPM

Single-cell type

  • microglia: 1,136 nCPM
  • b-cells: 767 nCPM
  • pituitary stem cells: 762 nCPM
  • epididymal principal cells: 592 nCPM
  • mucous neck cells: 377 nCPM
  • foveolar cells: 359 nCPM

Immune cell

  • naive B-cell: 87 nTPM
  • memory B-cell: 72 nTPM
  • basophil: 43 nTPM
  • myeloid DC: 21 nTPM
  • eosinophil: 19 nTPM
  • neutrophil: 4.3 nTPM

Brain region

  • white matter: 42 nTPM
  • medulla oblongata: 28 nTPM
  • pons: 24 nTPM
  • thalamus: 24 nTPM
  • spinal cord: 24 nTPM
  • hypothalamus: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
-0.92
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADAM28 as an antibody target. Whether an autoantibody or antibody against ADAM28 could matter depends on whether native ADAM28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADAM28 is annotated at the cell surface, where native ADAM28 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ADAM28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADAM28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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