Seroatlas · Human Serome Atlas

HSPB9

Heat shock protein beta-9

Also known as: CT51, HSPB9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQS6
Gene
HSPB9
Ensembl
ENSG00000260325
Chromosome
17
Canonical length
159 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

159 residues, UniProt reviewed canonical sequence.

>Q9BQS6|HSPB9
     1  MQRVGNTFSN ESRVASRCPS VGLAERNRVA TMPVRLLRDS PAAQEDNDHA RDGFQMKLDA
    61  HGFAPEELVV QVDGQWLMVT GQQQLDVRDP ERVSYRMSQK VHRKMLPSNL SPTAMTCCLT
   121  PSGQLWVRGQ CVALALPEAQ TGPSPRLGSL GSKASNLTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HSPB9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
66 nTPM

Expression across tissuesHPA

Tissue

  • testis: 66 nTPM
  • liver: 8.9 nTPM
  • pancreas: 4.5 nTPM
  • salivary gland: 2.7 nTPM
  • ovary: 1.4 nTPM
  • skeletal muscle: 1.4 nTPM

Single-cell type

  • late spermatids: 1,561 nCPM
  • late primary spermatocytes: 373 nCPM
  • early spermatids: 362 nCPM
  • hepatocytes: 18 nCPM
  • oocytes: 9.2 nCPM
  • neuroendocrine cells: 4 nCPM

Immune cell

  • plasmacytoid DC: 0.5 nTPM
  • non-classical monocyte: 0.3 nTPM
  • classical monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • myeloid DC: 0.1 nTPM

Brain region

  • cerebellum: 2.1 nTPM
  • white matter: 2.1 nTPM
  • basal ganglia: 1.8 nTPM
  • cerebral cortex: 1.7 nTPM
  • hypothalamus: 1.7 nTPM
  • medulla oblongata: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z
0.14
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HSPB9 as an antibody target. Whether an autoantibody or antibody against HSPB9 could matter depends on whether native HSPB9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HSPB9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HSPB9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HSPB9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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