Seroatlas · Human Serome Atlas

PTGES3L

Putative protein PTGES3L

Also known as: PTG3L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
E9PB15
Gene
PTGES3L
Ensembl
ENSG00000267060
Chromosome
17
Canonical length
166 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable Hsp90 protein binding activity and protein-folding chaperone binding activity. Predicted to be involved in chaperone-mediated protein complex assembly and protein folding. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>E9PB15|PTGES3L
     1  MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR TLWYDRPRYV
    61  FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY AKVNSKPVWL SVDFDNWRDW
   121  EGDEEMELAH VEHYAELLKK VSTKRPPPAM DDLDDDSDSA DDATSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGES3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
117 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 117 nTPM
  • tongue: 89 nTPM
  • heart muscle: 27 nTPM
  • colon: 8.7 nTPM
  • smooth muscle: 6.7 nTPM
  • endometrium: 5.1 nTPM

Single-cell type

  • megakaryocytes: 6.2 nCPM
  • brain inhibitory neurons: 6 nCPM
  • brain excitatory neurons: 3.3 nCPM
  • ependymal cells: 3 nCPM
  • other brain neurons: 3 nCPM
  • choroid plexus epithelial cells: 1.6 nCPM

Immune cell

  • plasmacytoid DC: 4.1 nTPM
  • basophil: 0.6 nTPM
  • neutrophil: 0.4 nTPM
  • total PBMC: 0.4 nTPM
  • naive B-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • basal ganglia: 7.9 nTPM
  • cerebral cortex: 7.2 nTPM
  • white matter: 6.4 nTPM
  • cerebellum: 5.5 nTPM
  • amygdala: 5.3 nTPM
  • pons: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0.01
gnomAD missense Z
0.19
DepMap mean gene effect
0.02
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGES3L as an antibody target. Whether an autoantibody or antibody against PTGES3L could matter depends on whether native PTGES3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGES3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGES3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTGES3L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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