Seroatlas · Human Serome Atlas

NUDCD1

NudC domain-containing protein 1

Also known as: CML66, FLJ14991, NUDC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RS6
Gene: NUDCD1
Ensembl: ENSG00000120526
Chromosome: 8
Canonical length: 583 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in immune system process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>Q96RS6|NUDCD1
     1  MEVAANCSLR VKRPLLDPRF EGYKLSLEPL PCYQLELDAA VAEVKLRDDQ YTLEHMHAFG
    61  MYNYLHCDSW YQDSVYYIDT LGRIMNLTVM LDTALGKPRE VFRLPTDLTA CDNRLCASIH
   121  FSSSTWVTLS DGTGRLYVIG TGERGNSASE KWEIMFNEEL GDPFIIIHSI SLLNAEEHSI
   181  ATLLLRIEKE ELDMKGSGFY VSLEWVTISK KNQDNKKYEI IKRDILRGKS VPHYAAIEPD
   241  GNGLMIVSYK SLTFVQAGQD LEENMDEDIS EKIKEPLYYW QQTEDDLTVT IRLPEDSTKE
   301  DIQIQFLPDH INIVLKDHQF LEGKLYSSID HESSTWIIKE SNSLEISLIK KNEGLTWPEL
   361  VIGDKQGELI RDSAQCAAIA ERLMHLTSEE LNPNPDKEKP PCNAQELEEC DIFFEESSSL
   421  CRFDGNTLKT THVVNLGSNQ YLFSVIVDPK EMPCFCLRHD VDALLWQPHS SKQDDMWEHI
   481  ATFNALGYVQ ASKRDKKFFA CAPNYSYAAL CECLRRVFIY RQPAPMSTVL YNRKEGRQVG
   541  QVAKQQVASL ETNDPILGFQ ATNERLFVLT TKNLFLIKVN TEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDCD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

placenta: 14 nTPM
testis: 11 nTPM
urinary bladder: 11 nTPM
adipose tissue: 10 nTPM
thymus: 9.4 nTPM
breast: 8.9 nTPM

Single-cell type

late primary spermatocytes: 146 nCPM
podocytes: 109 nCPM
early spermatids: 85 nCPM
vascular endothelial cells: 67 nCPM
early primary spermatocytes: 65 nCPM
mesothelial cells: 54 nCPM

Immune cell

memory CD8 T-cell: 1.7 nTPM
NK-cell: 1.7 nTPM
non-classical monocyte: 1.7 nTPM
naive CD8 T-cell: 1.6 nTPM
T-reg: 1.6 nTPM
MAIT T-cell: 1.5 nTPM

Brain region

spinal cord: 4.1 nTPM
white matter: 3.6 nTPM
medulla oblongata: 3.3 nTPM
cerebellum: 3.2 nTPM
cerebral cortex: 3 nTPM
midbrain: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

immune system process

Cellular components

Protein domainsUniProt · Pfam · InterPro

CS domain
HSP20-like chaperone
CS domain
NudC domain-containing protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDCD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDCD1 as an antibody target. Whether an autoantibody or antibody against NUDCD1 could matter depends on whether native NUDCD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDCD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDCD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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