Seroatlas · Human Serome Atlas

NUDCD2

NudC domain-containing protein 2

Also known as: DKFZp686E10109, NUDC2_HUMAN, NudCL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVJ2
Gene: NUDCD2
Ensembl: ENSG00000170584
Chromosome: 5
Canonical length: 157 aa
Protein class: Predicted intracellular proteins
Subcellular location: Microtubules,Cytokinetic bridge,Mitotic spindle,Cytosol

OverviewNCBI Gene

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in cytosol; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

157 residues, UniProt reviewed canonical sequence.

>Q8WVJ2|NUDCD2
     1  MSAPFEERSG VVPCGTPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR HVALSVGGRE
    61  ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW TSLLESEYAA DPWVQDQMQR
   121  KLTLERFQKE NPGFDFSGAE ISGNYTKGGP DFSNLEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDCD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 25 nTPM
skeletal muscle: 20 nTPM
midbrain: 18 nTPM
hippocampal formation: 15 nTPM
basal ganglia: 15 nTPM
pancreas: 15 nTPM

Single-cell type

cytotrophoblasts: 146 nCPM
late primary spermatocytes: 134 nCPM
esophageal basal cells: 129 nCPM
migrating cytotrophoblasts: 121 nCPM
epididymal principal cells: 120 nCPM
esophageal suprabasal cells: 117 nCPM

Immune cell

memory B-cell: 92 nTPM
naive CD4 T-cell: 89 nTPM
memory CD4 T-cell: 84 nTPM
NK-cell: 84 nTPM
T-reg: 84 nTPM
plasmacytoid DC: 81 nTPM

Brain region

white matter: 25 nTPM
medulla oblongata: 17 nTPM
pons: 17 nTPM
cerebellum: 16 nTPM
basal ganglia: 16 nTPM
spinal cord: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein folding

Molecular functions

unfolded protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

CS domain
HSP20-like chaperone
NudC family
CS domain
NudC domain-containing protein 2, p23 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDCD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDCD2 as an antibody target. Whether an autoantibody or antibody against NUDCD2 could matter depends on whether native NUDCD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDCD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDCD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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