HSPB7
Heat shock protein beta-7
Also known as: cvHSP, HSPB7_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UBY9
- Gene
- HSPB7
- Ensembl
- ENSG00000173641
- Chromosome
- 1
- Canonical length
- 170 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a small heat shock family B member that can heterodimerize with similar heat shock proteins. Defects in this gene are associated with advanced heart failure. In addition, the encoded protein may be a tumor suppressor in the p53 pathway, with defects in this gene being associated with renal cell carcinoma. [provided by RefSeq, Mar 2017]
Canonical amino-acid sequenceUniProt
170 residues, UniProt reviewed canonical sequence.
>Q9UBY9|HSPB7
1 MSHRTSSTFR AERSFHSSSS SSSSSTSSSA SRALPAQDPP MEKALSMFSD DFGSFMRPHS
61 EPLAFPARPG GAGNIKTLGD AYEFAVDVRD FSPEDIIVTT SNNHIEVRAE KLAADGTVMN
121 TFAHKCQLPE DVDPTSVTSA LREDGSLTIR ARRHPHTEHV QQTFRTEIKILocalizationUniProt · AlphaFold · HPA
Whether an antibody against HSPB7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 3,568 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 3,568 nTPM
- skeletal muscle: 2,065 nTPM
- tongue: 1,148 nTPM
- blood vessel: 577 nTPM
- adipose tissue: 288 nTPM
- smooth muscle: 177 nTPM
Single-cell type
- thymic myoid cells: 582 nCPM
- cardiomyocytes: 494 nCPM
- myonuclei: 232 nCPM
- late spermatids: 130 nCPM
- smooth muscle cells: 81 nCPM
- vascular smooth muscle cells: 76 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 22 nTPM
- pons: 20 nTPM
- cerebellum: 13 nTPM
- choroid plexus: 13 nTPM
- midbrain: 13 nTPM
- white matter: 9.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.58
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.43
- DepMap mean gene effect
- -0.19
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Alpha crystallin/Small heat shock protein, animal type
- Alpha crystallin/Hsp20 domain
- HSP20-like chaperone
- Hsp20/alpha crystallin family
- Heat shock protein beta-7, ACD domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HSPB7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HSPB7 as an antibody target. Whether an autoantibody or antibody against HSPB7 could matter depends on whether native HSPB7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HSPB7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label HSPB7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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