AMP-dependent synthetase/ligase domain

Definition

This domain is found in a number of prokaryotic and eukaryotic enzymes, which act via an ATP-dependent covalent binding of AMP to their substrate, share a region of sequence similarity [[cite:PMID:2118102], [cite:PMID:2911486], [cite:PMID:2254270]]. This region is a Ser/Thr/Gly-rich domain that is further characterised by a conserved Pro-Lys-Gly triplet. This group of enzymes includes luciferase, long chain fatty acid Co-A ligase, long-chain fatty acid transport proteins that also function as acyl-CoA ligases, acetyl-CoA synthetase and various other closely-related synthetases [[cite:PMID:8805533], [cite:PMID:26473393], [cite:PMID:15699031]].

30 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (30 proteins: gene, accession, name)

• AACS
• AASDH
• ACSBG1
• ACSBG2
• ACSF2
• ACSF3
• ACSL1
• ACSL3
• ACSL4
• ACSL5
• ACSL6
• ACSM1
• ACSM2A
• ACSM2B
• ACSM3
• ACSM4
• ACSM5
• ACSM6
• ACSS1
• ACSS2
• ACSS3
• DIP2A
• DIP2B
• DIP2C
• SLC27A1
• SLC27A2
• SLC27A3
• SLC27A4
• SLC27A5
• SLC27A6