Seroatlas · Human Serome Atlas

ACSL6

Long-chain-fatty-acid--CoA ligase 6

Also known as: ACS2, ACSL6_HUMAN, FACL6, KIAA0837, LACS2, LACS5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UKU0
Gene
ACSL6
Ensembl
ENSG00000164398
Chromosome
5
Canonical length
697 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q9UKU0|ACSL6
     1  MQTQEILRIL RLPELGDLGQ FFRSLSATTL VSMGALAAIL AYWFTHRPKA LQPPCNLLMQ
    61  SEEVEDSGGA RRSVIGSGPQ LLTHYYDDAR TMYQVFRRGL SISGNGPCLG FRKPKQPYQW
   121  LSYQEVADRA EFLGSGLLQH NCKACTDQFI GVFAQNRPEW IIVELACYTY SMVVVPLYDT
   181  LGPGAIRYII NTADISTVIV DKPQKAVLLL EHVERKETPG LKLIILMDPF EEALKERGQK
   241  CGVVIKSMQA VEDCGQENHQ APVPPQPDDL SIVCFTSGTT GNPKGAMLTH GNVVADFSGF
   301  LKVTEKVIFP RQDDVLISFL PLAHMFERVI QSVVYCHGGR VGFFQGDIRL LSDDMKALCP
   361  TIFPVVPRLL NRMYDKIFSQ ANTPLKRWLL EFAAKRKQAE VRSGIIRNDS IWDELFFNKI
   421  QASLGGCVRM IVTGAAPASP TVLGFLRAAL GCQVYEGYGQ TECTAGCTFT TPGDWTSGHV
   481  GAPLPCNHIK LVDVEELNYW ACKGEGEICV RGPNVFKGYL KDPDRTKEAL DSDGWLHTGD
   541  IGKWLPAGTL KIIDRKKHIF KLAQGEYVAP EKIENIYIRS QPVAQIYVHG DSLKAFLVGI
   601  VVPDPEVMPS WAQKRGIEGT YADLCTNKDL KKAILEDMVR LGKESGLHSF EQVKAIHIHS
   661  DMFSVQNGLL TPTLKAKRPE LREYFKKQIE ELYSISM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • retina: 42 nTPM
  • cerebral cortex: 30 nTPM
  • cerebellum: 28 nTPM
  • bone marrow: 21 nTPM
  • amygdala: 20 nTPM
  • testis: 19 nTPM

Single-cell type

  • late primary spermatocytes: 5.3 nCPM
  • astrocytes: 4.2 nCPM
  • bergmann glia: 3.5 nCPM
  • rod photoreceptor cells: 1.6 nCPM
  • early spermatids: 1.5 nCPM
  • retinal amacrine cells: 1.4 nCPM

Immune cell

  • memory CD8 T-cell: 1.6 nTPM
  • MAIT T-cell: 1.1 nTPM
  • naive CD4 T-cell: 1.1 nTPM
  • memory CD4 T-cell: 0.7 nTPM
  • naive CD8 T-cell: 0.5 nTPM
  • gdT-cell: 0.4 nTPM

Brain region

  • cerebral cortex: 85 nTPM
  • cerebellum: 75 nTPM
  • thalamus: 72 nTPM
  • medulla oblongata: 67 nTPM
  • pons: 59 nTPM
  • hippocampal formation: 58 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.48
gnomAD pLI
0
gnomAD missense Z
1.76
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSL6 as an antibody target. Whether an autoantibody or antibody against ACSL6 could matter depends on whether native ACSL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACSL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACSL6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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