Seroatlas · Human Serome Atlas

SLC27A4

Long-chain fatty acid transport protein 4

Also known as: ACSVL4, FATP4, S27A4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6P1M0
Gene
SLC27A4
Ensembl
ENSG00000167114
Chromosome
9
Canonical length
643 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

643 residues, UniProt reviewed canonical sequence.

>Q6P1M0|SLC27A4
     1  MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR RDIFGGLVLL
    61  KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT HWTFRQLDEY SSSVANFLQA
   121  RGLASGDVAA IFMENRNEFV GLWLGMAKLG VEAALINTNL RRDALLHCLT TSRARALVFG
   181  SEMASAICEV HASLDPSLSL FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK
   241  LFYIYTSGTT GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ
   301  CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE NQHQVRMALG
   361  NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV GACGFNSRIL SFVYPIRLVR
   421  VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR IIQKDPLRRF DGYLNQGANN KKIAKDVFKK
   481  GDQAYLTGDV LVMDELGYLY FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE
   541  VPGTEGRAGM AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE
   601  LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC27A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
63 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 63 nTPM
  • esophagus: 59 nTPM
  • skin: 39 nTPM
  • small intestine: 39 nTPM
  • liver: 39 nTPM
  • cerebral cortex: 33 nTPM

Single-cell type

  • colonocytes: 572 nCPM
  • foveolar cells: 392 nCPM
  • enterocytes: 314 nCPM
  • gastric chief cells: 310 nCPM
  • goblet cells: 278 nCPM
  • parietal cells: 272 nCPM

Immune cell

  • gdT-cell: 4.7 nTPM
  • myeloid DC: 4.4 nTPM
  • non-classical monocyte: 4.4 nTPM
  • plasmacytoid DC: 4 nTPM
  • memory CD8 T-cell: 3.6 nTPM
  • MAIT T-cell: 3.4 nTPM

Brain region

  • cerebral cortex: 56 nTPM
  • pons: 54 nTPM
  • medulla oblongata: 50 nTPM
  • thalamus: 49 nTPM
  • hypothalamus: 47 nTPM
  • cerebellum: 46 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC27A4.

Disease | AllUniProt

Conditions SLC27A4 is implicated in, by any mechanism.

Disease | GeneticClinVar

51 pathogenic / likely-pathogenic of 550 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC27A4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC27A4 as an antibody target. Whether an autoantibody or antibody against SLC27A4 could matter depends on whether native SLC27A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC27A4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SLC27A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC27A4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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