SLC27A3

Protein identityUniProt · HPA

UniProt accession

Q5K4L6

Gene

SLC27A3

Ensembl

ENSG00000143554

Chromosome

1

Canonical length

683 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Endoplasmic reticulum,Mitochondria

OverviewNCBI Gene

This gene belongs to a family of integral membrane proteins and encodes a protein that is involved in lipid metabolism. The increased expression of this gene in human neural stem cells derived from induced pluripotent stem cells suggests that it plays an important role in early brain development. Naturally occurring mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

683 residues, UniProt reviewed canonical sequence.

>Q5K4L6|SLC27A3
     1  MAALLLLPLL LLLPLLLLKL HLWPQLRWLP ADLAFAVRAL CCKRALRARA LAAAAADPEG
    61  PEGGCSLAWR LAELAQQRAA HTFLIHGSRR FSYSEAERES NRAARAFLRA LGWDWGPDGG
   121  DSGEGSAGEG ERAAPGAGDA AAGSGAEFAG GDGAARGGGA AAPLSPGATV ALLLPAGPEF
   181  LWLWFGLAKA GLRTAFVPTA LRRGPLLHCL RSCGARALVL APEFLESLEP DLPALRAMGL
   241  HLWAAGPGTH PAGISDLLAE VSAEVDGPVP GYLSSPQSIT DTCLYIFTSG TTGLPKAARI
   301  SHLKILQCQG FYQLCGVHQE DVIYLALPLY HMSGSLLGIV GCMGIGATVV LKSKFSAGQF
   361  WEDCQQHRVT VFQYIGELCR YLVNQPPSKA ERGHKVRLAV GSGLRPDTWE RFVRRFGPLQ
   421  VLETYGLTEG NVATINYTGQ RGAVGRASWL YKHIFPFSLI RYDVTTGEPI RDPQGHCMAT
   481  SPGEPGLLVA PVSQQSPFLG YAGGPELAQG KLLKDVFRPG DVFFNTGDLL VCDDQGFLRF
   541  HDRTGDTFRW KGENVATTEV AEVFEALDFL QEVNVYGVTV PGHEGRAGMA ALVLRPPHAL
   601  DLMQLYTHVS ENLPPYARPR FLRLQESLAT TETFKQQKVR MANEGFDPST LSDPLYVLDQ
   661  AVGAYLPLTT ARYSALLAGN LRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC27A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

38 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC27A3.

Disease | ImmuneIEDB

Conditions an epitope on SLC27A3 was assayed in.

• collecting duct carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

gnomAD missense Z

-1.35

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• fatty acid transport
• long-chain fatty acid metabolic process

Molecular functions

• arachidonate-CoA ligase activity
• ATP binding
• long-chain fatty acid-CoA ligase activity
• very long-chain fatty acid-CoA ligase activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• membrane
• mitochondrial membrane
• mitochondrion
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• AMP-dependent synthetase/ligase domain
• AMP-binding, conserved site
• AMP-binding enzyme, C-terminal domain
• ANL, N-terminal domain
• AMP-binding enzyme domain superfamily
• AMP-binding enzyme
• AMP-binding enzyme C-terminal domain

KeywordsUniProt

• ATP-binding
• Fatty acid metabolism
• Ligase
• Lipid metabolism
• Lipid transport
• Membrane
• Mitochondrion
• Nucleotide-binding
• Transmembrane
• Transmembrane helix
• Transport