Seroatlas · Human Serome Atlas

SLC27A5

Long-chain fatty acid transport protein 5

Also known as: ACSB, ACSVL6, FACVL3, FATP5, FLJ22987, S27A5_HUMAN, VLACSR, VLCS-H2, VLCSH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2P5
Gene
SLC27A5
Ensembl
ENSG00000083807
Chromosome
19
Canonical length
690 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

690 residues, UniProt reviewed canonical sequence.

>Q9Y2P5|SLC27A5
     1  MGVRQQLALL LLLLLLLWGL GQPVWPVAVA LTLRWLLGDP TCCVLLGLAM LARPWLGPWV
    61  PHGLSLAAAA LALTLLPARL PPGLRWLPAD VIFLAKILHL GLKIRGCLSR QPPDTFVDAF
   121  ERRARAQPGR ALLVWTGPGA GSVTFGELDA RACQAAWALK AELGDPASLC AGEPTALLVL
   181  ASQAVPALCM WLGLAKLGCP TAWINPHGRG MPLAHSVLSS GARVLVVDPD LRESLEEILP
   241  KLQAENIRCF YLSHTSPTPG VGALGAALDA APSHPVPADL RAGITWRSPA LFIYTSGTTG
   301  LPKPAILTHE RVLQMSKMLS LSGATADDVV YTVLPLYHVM GLVVGILGCL DLGATCVLAP
   361  KFSTSCFWDD CRQHGVTVIL YVGELLRYLC NIPQQPEDRT HTVRLAMGNG LRADVWETFQ
   421  QRFGPIRIWE VYGSTEGNMG LVNYVGRCGA LGKMSCLLRM LSPFELVQFD MEAAEPVRDN
   481  QGFCIPVGLG EPGLLLTKVV SQQPFVGYRG PRELSERKLV RNVRQSGDVY YNTGDVLAMD
   541  REGFLYFRDR LGDTFRWKGE NVSTHEVEGV LSQVDFLQQV NVYGVCVPGC EGKVGMAAVQ
   601  LAPGQTFDGE KLYQHVRAWL PAYATPHFIR IQDAMEVTST FKLMKTRLVR EGFNVGIVVD
   661  PLFVLDNRAQ SFRPLTAEMY QAVCEGTWRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC27A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
989 nTPM

Expression across tissuesHPA

Tissue

  • liver: 989 nTPM
  • amygdala: 41 nTPM
  • basal ganglia: 41 nTPM
  • cerebral cortex: 37 nTPM
  • choroid plexus: 33 nTPM
  • midbrain: 32 nTPM

Single-cell type

  • late spermatids: 808 nCPM
  • hepatocytes: 555 nCPM
  • late primary spermatocytes: 147 nCPM
  • early spermatids: 131 nCPM
  • oocytes: 74 nCPM
  • cardiomyocytes: 65 nCPM

Immune cell

  • MAIT T-cell: 30 nTPM
  • memory B-cell: 25 nTPM
  • T-reg: 23 nTPM
  • naive CD8 T-cell: 22 nTPM
  • naive CD4 T-cell: 21 nTPM
  • plasmacytoid DC: 18 nTPM

Brain region

  • thalamus: 20 nTPM
  • midbrain: 17 nTPM
  • basal ganglia: 16 nTPM
  • hypothalamus: 15 nTPM
  • amygdala: 15 nTPM
  • spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.21
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC27A5 as an antibody target. Whether an autoantibody or antibody against SLC27A5 could matter depends on whether native SLC27A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC27A5 is annotated at the cell surface, where native SLC27A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC27A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC27A5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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