Seroatlas · Human Serome Atlas

SLC27A1

Long-chain fatty acid transport protein 1

Also known as: ACSVL5, FATP, FATP1, FLJ00336, MGC71751, S27A1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PCB7
Gene
SLC27A1
Ensembl
ENSG00000130304
Chromosome
19
Canonical length
646 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Mitochondria,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Involved in export across plasma membrane; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

646 residues, UniProt reviewed canonical sequence.

>Q6PCB7|SLC27A1
     1  MRAPGAGAAS VVSLALLWLL GLPWTWSAAA ALGVYVGSGG WRFLRIVCKT ARRDLFGLSV
    61  LIRVRLELRR HQRAGHTIPR IFQAVVQRQP ERLALVDAGT GECWTFAQLD AYSNAVANLF
   121  RQLGFAPGDV VAIFLEGRPE FVGLWLGLAK AGMEAALLNV NLRREPLAFC LGTSGAKALI
   181  FGGEMVAAVA EVSGHLGKSL IKFCSGDLGP EGILPDTHLL DPLLKEASTA PLAQIPSKGM
   241  DDRLFYIYTS GTTGLPKAAI VVHSRYYRMA AFGHHAYRMQ AADVLYDCLP LYHSAGNIIG
   301  VGQCLIYGLT VVLRKKFSAS RFWDDCIKYN CTVVQYIGEI CRYLLKQPVR EAERRHRVRL
   361  AVGNGLRPAI WEEFTERFGV RQIGEFYGAT ECNCSIANMD GKVGSCGFNS RILPHVYPIR
   421  LVKVNEDTME LLRDAQGLCI PCQAGEPGLL VGQINQQDPL RRFDGYVSES ATSKKIAHSV
   481  FSKGDSAYLS GDVLVMDELG YMYFRDRSGD TFRWRGENVS TTEVEGVLSR LLGQTDVAVY
   541  GVAVPGVEGK AGMAAVADPH SLLDPNAIYQ ELQKVLAPYA RPIFLRLLPQ VDTTGTFKIQ
   601  KTRLQREGFD PRQTSDRLFF LDLKQGHYLP LNEAVYTRIC SGAFAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC27A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.23
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 45 nTPM
  • cerebellum: 38 nTPM
  • ovary: 33 nTPM
  • heart muscle: 28 nTPM
  • basal ganglia: 28 nTPM
  • spinal cord: 27 nTPM

Single-cell type

  • choroid plexus epithelial cells: 221 nCPM
  • bergmann glia: 163 nCPM
  • myonuclei: 139 nCPM
  • cardiomyocytes: 137 nCPM
  • astrocytes: 130 nCPM
  • adipocytes: 91 nCPM

Immune cell

  • classical monocyte: 9.1 nTPM
  • plasmacytoid DC: 6.5 nTPM
  • myeloid DC: 6.3 nTPM
  • total PBMC: 4.6 nTPM
  • intermediate monocyte: 4 nTPM
  • MAIT T-cell: 2.6 nTPM

Brain region

  • choroid plexus: 69 nTPM
  • white matter: 68 nTPM
  • basal ganglia: 59 nTPM
  • medulla oblongata: 59 nTPM
  • midbrain: 57 nTPM
  • cerebellum: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.23
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC27A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC27A1 as an antibody target. Whether an autoantibody or antibody against SLC27A1 could matter depends on whether native SLC27A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC27A1 is annotated at the cell surface, where native SLC27A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC27A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC27A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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