ACSM2A

Protein identityUniProt · HPA

UniProt accession

Q08AH3

Gene

ACSM2A

Ensembl

ENSG00000183747

Chromosome

16

Canonical length

577 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q08AH3|ACSM2A
     1  MHWLRKVQGL CTLWGTQMSS RTLYINSRQL VSLQWGHQEV PAKFNFASDV LDHWADMEKA
    61  GKRLPSPALW WVNGKGKELM WNFRELSENS QQAANVLSGA CGLQRGDRVA VVLPRVPEWW
   121  LVILGCIRAG LIFMPGTIQM KSTDILYRLQ MSKAKAIVAG DEVIQEVDTV ASECPSLRIK
   181  LLVSEKSCDG WLNFKKLLNE ASTTHHCVET GSQEASAIYF TSGTSGLPKM AEHSYSSLGL
   241  KAKMDAGWTG LQASDIMWTI SDTGWILNIL CSLMEPWALG ACTFVHLLPK FDPLVILKTL
   301  SSYPIKSMMG APIVYRMLLQ QDLSSYKFPH LQNCVTVGES LLPETLENWR AQTGLDIRES
   361  YGQTETGLTC MVSKTMKIKP GYMGTAASCY DVQIIDDKGN VLPPGTEGDI GIRVKPIRPI
   421  GIFSGYVDNP DKTAANIRGD FWLLGDRGIK DEDGYFQFMG RANDIINSSG YRIGPSEVEN
   481  ALMEHPAVVE TAVISSPDPV RGEVVKAFVV LASQFLSHDP EQLTKELQQH VKSVTAPYKY
   541  PRKIEFVLNL PKTVTGKIQR AKLRDKEWKM SGKARAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSM2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.24

Highest tissue expression

350 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.36

gnomAD pLI

0

gnomAD missense Z

-1.79

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• acyl-CoA metabolic process
• fatty acid biosynthetic process
• glucose homeostasis
• medium-chain fatty-acyl-CoA metabolic process
• triglyceride homeostasis

Molecular functions

• ATP binding
• benzoate-CoA ligase activity
• decanoate-CoA ligase activity
• fatty acid ligase activity
• fatty-acyl-CoA synthase activity
• medium-chain fatty acid-CoA ligase activity
• metal ion binding

Cellular components

• mitochondrial matrix
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• AMP-dependent synthetase/ligase domain
• AMP-binding, conserved site
• AMP-binding enzyme, C-terminal domain
• ANL, N-terminal domain
• AMP-binding enzyme domain superfamily
• Mitochondrial Acyl-CoA Synthetase Medium-Chain
• AMP-binding enzyme
• AMP-binding enzyme C-terminal domain

KeywordsUniProt

• ATP-binding
• Fatty acid metabolism
• Ligase
• Lipid metabolism
• Magnesium
• Metal-binding
• Mitochondrion
• Nucleotide-binding
• Phosphoprotein
• Transit peptide