Seroatlas · Human Serome Atlas

ACSBG1

Long-chain-fatty-acid--CoA ligase ACSBG1

Also known as: ACBG1_HUMAN, BG1, BGM, FLJ30320, hBG1, hsBG, KIAA0631, MGC14352

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96GR2
Gene
ACSBG1
Ensembl
ENSG00000103740
Chromosome
15
Canonical length
724 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

724 residues, UniProt reviewed canonical sequence.

>Q96GR2|ACSBG1
     1  MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA
    61  LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI
   121  ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA
   181  GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP
   241  NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
   301  WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL
   361  VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL
   421  KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMMAETQ HFFLGLNIRL YAGYGLSETS
   481  GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI
   541  DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
   601  GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA
   661  IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ
   721  EQKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSBG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 39 nTPM
  • basal ganglia: 35 nTPM
  • midbrain: 29 nTPM
  • cerebral cortex: 26 nTPM
  • amygdala: 23 nTPM
  • hippocampal formation: 16 nTPM

Single-cell type

  • astrocytes: 363 nCPM
  • bergmann glia: 162 nCPM
  • cardiomyocytes: 119 nCPM
  • oocytes: 97 nCPM
  • oligodendrocytes: 83 nCPM
  • differentiating spermatogonia: 74 nCPM

Immune cell

  • plasmacytoid DC: 1 nTPM
  • total PBMC: 0.3 nTPM
  • neutrophil: 0.2 nTPM
  • basophil: 0.1 nTPM
  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM

Brain region

  • white matter: 133 nTPM
  • medulla oblongata: 115 nTPM
  • spinal cord: 114 nTPM
  • basal ganglia: 102 nTPM
  • midbrain: 99 nTPM
  • pons: 93 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
gnomAD missense Z
1.83
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSBG1 as an antibody target. Whether an autoantibody or antibody against ACSBG1 could matter depends on whether native ACSBG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSBG1 is annotated at the cell surface, where native ACSBG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ACSBG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ACSBG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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