Seroatlas · Human Serome Atlas

ACSM2B

Acyl-coenzyme A synthetase ACSM2B, mitochondrial

Also known as: ACS2B_HUMAN, ACSM2, HXMA, HYST1046

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68CK6
Gene: ACSM2B
Ensembl: ENSG00000066813
Chromosome: 16
Canonical length: 577 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Enables benzoate-CoA ligase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q68CK6|ACSM2B
     1  MHWLRKVQGL CTLWGTQMSS RTLYINSRQL VSLQWGHQEV PAKFNFASDV LDHWADMEKA
    61  GKRLPSPALW WVNGKGKELM WNFRELSENS QQAANILSGA CGLQRGDRVA VMLPRVPEWW
   121  LVILGCIRAG LIFMPGTIQM KSTDILYRLQ MSKAKAIVAG DEVIQEVDTV ASECPSLRIK
   181  LLVSEKSCDG WLNFKKLLNE ASTTHHCVET GSQEASAIYF TSGTSGLPKM AEHSYSSLGL
   241  KAKMDAGWTG LQASDIMWTI SDTGWILNIL GSLLESWTLG ACTFVHLLPK FDPLVILKTL
   301  SSYPIKSMMG APIVYRMLLQ QDLSSYKFPH LQNCLAGGES LLPETLENWR AQTGLDIREF
   361  YGQTETGLTC MVSKTMKIKP GYMGTAASCY DVQVIDDKGN VLPPGTEGDI GIRVKPIRPI
   421  GIFSGYVENP DKTAANIRGD FWLLGDRGIK DEDGYFQFMG RADDIINSSG YRIGPSEVEN
   481  ALMKHPAVVE TAVISSPDPV RGEVVKAFVI LASQFLSHDP EQLTKELQQH VKSVTAPYKY
   541  PRKIEFVLNL PKTVTGKIQR TKLRDKEWKM SGKARAQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ACSM2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 510 nTPM

Expression across tissuesHPA

Tissue

liver: 510 nTPM
kidney: 386 nTPM
cerebral cortex: 1.3 nTPM
thyroid gland: 1 nTPM
testis: 0.9 nTPM
colon: 0.8 nTPM

Single-cell type

proximal tubule cells: 2,116 nCPM
hepatocytes: 1,416 nCPM
renal connecting tubule cells: 27 nCPM
distal convoluted tubule cells: 26 nCPM
cholangiocytes: 26 nCPM
epididymal efferent duct absorptive cells: 25 nCPM

Immune cell

naive CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 13 nTPM
cerebral cortex: 10 nTPM
basal ganglia: 9.5 nTPM
hypothalamus: 8.7 nTPM
midbrain: 8.5 nTPM
pons: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -1.98
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ACSM2B as an antibody target. Whether an autoantibody or antibody against ACSM2B could matter depends on whether native ACSM2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ACSM2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ACSM2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...